Dubravko Jelić

TL;DR: Docking study showed that flavonoids bind to the BChE active site by forming multiple hydrogen bonds and pi-pi interactions, and UV-VIS absorption spectra of the flavonoid phosphate buffer solution revealed time dependant changes indicating precipitation of Flavonoids or in the case of myricetin, a change in the chemical structure resulting in a BChChE non-inhibiting specie.

TL;DR: A novel class of antibiotic compounds—macrolones, which are derived from macrolides and comprise macrocyclic moiety, linker, and either free or esterified quinolone 3-carboxylic group, show excellent antibacterial potency towards key erythromycin-resistant Gram-positive and Gram-negative bacterial strains, with possibly decreased potential of bacterial resistance to macrolide antibiotics.

TL;DR: The potency of the oximes K048 and K027 to protect mice from five-fold LD50 oftabun and their low toxicity make these compounds leading in the therapy of tabun poisoning.

TL;DR: Pro-inflammatory function of extracellular Hsp70 is confirmed, and its possible implication in COPD exacerbations caused by bacterial infection through desensitization or inappropriate activation of TLR2 and TLR4 receptors is suggested.

TL;DR: The obtained protection in VX poisoning outlines its potential in development oxime-assisted OP-bioscavenging with BChE, and the cytotoxicity of lead oximes is determined, considering the strict criteria set for in vivo applications.