Zrinka Kovarik

TL;DR: Docking study showed that flavonoids bind to the BChE active site by forming multiple hydrogen bonds and pi-pi interactions, and UV-VIS absorption spectra of the flavonoid phosphate buffer solution revealed time dependant changes indicating precipitation of Flavonoids or in the case of myricetin, a change in the chemical structure resulting in a BChChE non-inhibiting specie.

TL;DR: The potency of the oximes K048 and K027 to protect mice from five-fold LD50 oftabun and their low toxicity make these compounds leading in the therapy of tabun poisoning.

TL;DR: The synthesis and activity of a new series of oxime reactivators of cholinesterases (ChEs) that contain tertiary amine or imidazole protonatable functional groups are described, revealing that distinct reactivator ionization states are involved in the reactivation of ChE conjugates and in conferring nucleophilic reactivity of the oxime group.

TL;DR: In this article, the authors measured the oximolysis between oximes (K027 and HI-6) and ATCh in the presence of DTNB at different pH values, taking into account the final concentration of a product that is thiocholine.

TL;DR: The enhanced intrinsic reactivity against the OP-AChE target combined with favorable pharmacokinetic properties resulted in great improvement of antidotal properties of RS194B compared with RS41A and the standard peripherally active oxime, 2-pyridinealdoxime methiodide.