D
Daniel Kim
Researcher at Gladstone Institutes
Publications - 16
Citations - 2164
Daniel Kim is an academic researcher from Gladstone Institutes. The author has contributed to research in topics: Amyloid precursor protein & Alzheimer's disease. The author has an hindex of 14, co-authored 16 publications receiving 1763 citations.
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Journal ArticleDOI
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
Moustapha Cisse,Brian Halabisky,Julie A. Harris,Nino Devidze,Dena B. Dubal,Binggui Sun,Anna G. Orr,Gregor P. Lotz,Daniel Kim,Patricia Hamto,Kaitlyn Ho,Gui-Qiu Yu,Lennart Mucke +12 more
TL;DR: It is shown that amyloid-β oligomers bind to the fibronectin repeats domain of EphB2 and trigger EPhB2 degradation in the proteasome, which is critical in amyloids-β-induced neuronal dysfunction in Alzheimer’s disease.
Journal ArticleDOI
Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network
Julie A. Harris,Nino Devidze,Laure Verret,Kaitlyn Ho,Brian Halabisky,Myo T. Thwin,Daniel Kim,Patricia Hamto,Iris Lo,Gui-Qiu Yu,Jorge J. Palop,Eliezer Masliah,Lennart Mucke +12 more
TL;DR: APP/Aβ expression in EC neurons causes transsynaptic deficits that could initiate the cortical-hippocampal network dysfunction in mouse models and human patients with AD.
Journal ArticleDOI
Life Extension Factor Klotho Enhances Cognition
Dena B. Dubal,Jennifer S. Yokoyama,Lei Zhu,Lauren Broestl,Kurtresha Worden,Dan Wang,Virginia E. Sturm,Daniel Kim,Eric Klein,Gui Qiu Yu,Kaitlyn Ho,Kirsten Eilertson,Lei Yu,Makoto Kuro-o,Makoto Kuro-o,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Giovanni Coppola,Gary W. Small,David A. Bennett,Joel H. Kramer,Carmela R. Abraham,Bruce L. Miller,Lennart Mucke +24 more
TL;DR: It is shown that a lifespan-extending variant of the human KLOTHO gene, KL-VS, is associated with enhanced cognition in heterozygous carriers and may enhance cognition and counteract cognitive deficits at different life stages.
Journal ArticleDOI
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
Anna G. Orr,Edward C. Hsiao,Max M Wang,Kaitlyn Ho,Daniel Kim,Xin Wang,Weikun Guo,Jing Kang,Gui-Qiu Yu,Anthony Adame,Nino Devidze,Dena B. Dubal,Eliezer Masliah,Bruce R. Conklin,Lennart Mucke +14 more
TL;DR: Findings establish a regulatory role for astrocytic Gs-coupled receptors in memory and suggest that AD-linked increases in astroCytic A2A receptor levels contribute to memory loss.
Journal ArticleDOI
Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice
Dena B. Dubal,Lei Zhu,Pascal E. Sanchez,Kurtresha Worden,Lauren Broestl,Erik C. B. Johnson,Kaitlyn Ho,Gui Qiu Yu,Daniel Kim,Alexander Betourne,Makoto Kuro-o,Eliezer Masliah,Carmela R. Abraham,Lennart Mucke +13 more
TL;DR: It is shown that elevating klotho expression decreases premature mortality and network dysfunction in human amyloid precursor protein (hAPP) transgenic mice, which simulate key aspects of AD.