L
Lennart Mucke
Researcher at University of California, San Francisco
Publications - 196
Citations - 47763
Lennart Mucke is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Amyloid precursor protein & Alzheimer's disease. The author has an hindex of 97, co-authored 195 publications receiving 43172 citations. Previous affiliations of Lennart Mucke include Harvard University & Gladstone Institutes.
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Journal ArticleDOI
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.
Dora Games,David S. Adams,Ree Alessandrini,Robin Barbour,Patricia Borthelette,Catherine Blackwell,Tony Carr,J. C. Clemens,Thomas Donaldson,Frances Gillespie,Terry Guido,Stephanie Hagopian,Kelly Johnson-Wood,Karen Khan,Michael K. Lee,Paul Leibowitz,Ivan Lieberburg,Sheila P. Little,Eliezer Masliah,Lisa McConlogue,Martin Montoya-Zavala,Lennart Mucke,Lisa Paganini,Elizabeth Penniman,Michael Power,Dale Schenk,Peter Seubert,Ben W. Snyder,Ferdie Soriano,Hua Tan,James Vitale,Sam Wadsworth,Ben Wolozin,Jun Zhao +33 more
TL;DR: Transgenic mice that express high levels of human mutant APP support a primary role for APP/Aβ in the genesis of AD and could provide a preclinical model for testing therapeutic drugs.
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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.
Lennart Mucke,Eliezer Masliah,Gui-Qiu Yu,Margaret Mallory,Edward Rockenstein,Gwen Tatsuno,Kang Hu,Dora Kholodenko,Kelly Johnson-Wood,Lisa McConlogue +9 more
TL;DR: It is concluded that Aβ is synaptotoxic even in the absence of plaques and that high levels of Aβ1–42 are insufficient to induce plaque formation in mice expressing wild-type hAPP, supporting the emerging view that plaque-independent Aβ toxicity plays an important role in the development of synaptic deficits in AD and related conditions.
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Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
Erik D. Roberson,Kimberly Scearce-Levie,Jorge J. Palop,Fengrong Yan,Irene H. Cheng,Tiffany Wu,Hilary Gerstein,Gui Qiu Yu,Lennart Mucke +8 more
TL;DR: Reducing endogenous tau levels prevented behavioral deficits in transgenic mice expressing human amyloid precursor protein, without altering their high Aβ levels, and protected both transgenic and nontransgenic mice against excitotoxicity.
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Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders
Eliezer Masliah,Edward Rockenstein,Isaac Veinbergs,Margaret Mallory,Makoto Hashimoto,Ayako Takeda,Yutaka Sagara,Abbyann Sisk,Lennart Mucke +8 more
TL;DR: Results suggest that accumulation of wild-type alpha-synuclein may play a causal role in Parkinson's disease and related conditions.
Journal ArticleDOI
Alzheimer mechanisms and therapeutic strategies.
Yadong Huang,Lennart Mucke +1 more
TL;DR: Investigative and drug development efforts should be diversified to fully address the multifactoriality of Alzheimer's disease.