Daniel L. Alkon

TL;DR: The back-propagation algorithm described by Rumelhart et al. (1986) can greatly accelerate convergence as discussed by the authors, however, in many applications, the number of iterations required before convergence can be large.

TL;DR: The findings suggest that IR may participate in memory processing through activation of its receptor Tyr kinase activity, and they suggest possible engagement of Shc/Grb-2/Ras/mitogen-activated protein kinase cascades.

TL;DR: Emerging evidence has suggested that insulin signaling plays a role in synaptic plasticity by modulating activities of excitatory and inhibitory receptors such as glutamate and GABA receptors, and by triggering signal transduction cascades leading to alteration of gene expression required for long-term memory consolidation.

TL;DR: Bombesin-induced Ca2+ release, which is inositol trisphosphate-mediated, is shown here to be greatly enhanced in AD fibroblasts compared with fibroBlasts from control groups, suggesting that the differences in bombesin and bradykinin responses in fibro Blasts and perhaps other cell types are likely to be due to alteration of inositl tr isphosphates-mediated release of intracellular Ca2+.

TL;DR: Bryostatin 1 at subnanomolar concentrations dramatically enhances the secretion of the alpha-secretase product sAPP alpha in fibroblasts from AD patients, corroborate PKC and its activation as a potentially important means of ameliorating AD pathophysiology and perhaps cognitive impairment.