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Alan P. Kozikowski
Researcher at Georgetown University
Publications - 393
Citations - 10771
Alan P. Kozikowski is an academic researcher from Georgetown University. The author has contributed to research in topics: Huperzine A & Protein kinase C. The author has an hindex of 52, co-authored 390 publications receiving 10207 citations. Previous affiliations of Alan P. Kozikowski include University of Illinois at Urbana–Champaign & Princeton University.
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Journal ArticleDOI
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Mia L. Raves,Michal Harel,Yuan Ping Pang,Israel Silman,Alan P. Kozikowski,Joel L. Sussman,Joel L. Sussman +6 more
TL;DR: An analysis of the affinities of structural analogues of HupA, correlated with their interactions with the protein, shows the importance of individual hydrophobic interactions between H upA and aromatic residues in the active-site gorge of AChE.
Journal ArticleDOI
Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice.
Rene Etcheberrigaray,Mathew Tan,Ilse Dewachter,Cuno Kuiperi,Ingrid Van der Auwera,Stefaan Wera,Lixin Qiao,Barry Bank,Thomas J. Nelson,Alan P. Kozikowski,Fred Van Leuven,Daniel L. Alkon +11 more
TL;DR: Bryostatin 1 at subnanomolar concentrations dramatically enhances the secretion of the alpha-secretase product sAPP alpha in fibroblasts from AD patients, corroborate PKC and its activation as a potentially important means of ameliorating AD pathophysiology and perhaps cognitive impairment.
Journal ArticleDOI
Design of Remarkably Simple, Yet Potent Urea-Based Inhibitors of Glutamate Carboxypeptidase II (NAALADase)
Alan P. Kozikowski,Fajun Nan,Paola Conti,Jiazhong Zhang,Epolia Ramadan,Tomasz Bzdega,Barbara Wroblewska,Joseph H. Neale,Sergey Pshenichkin,Jarda T. Wroblewski +9 more
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N-[N-[(S)-1,3-Dicarboxypropyl]Carbamoyl]-4-[18F]Fluorobenzyl-l-Cysteine, [18F]DCFBC: A New Imaging Probe for Prostate Cancer
Ronnie C. Mease,Crystal L. Dusich,Catherine A. Foss,Hayden T. Ravert,Robert F. Dannals,Jurgen Seidel,Andrew Prideaux,James Fox,George Sgouros,Alan P. Kozikowski,Martin G. Pomper +10 more
TL;DR: [18F]DCFBC localizes to PSMA+-expressing tumors in mice, permitting imaging by small-animal PET, and is an attractive candidate for further studies of PET imaging of prostate cancer.