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Daniel Rösel
Researcher at Charles University in Prague
Publications - 67
Citations - 2451
Daniel Rösel is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Cancer cell & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 21, co-authored 64 publications receiving 1843 citations. Previous affiliations of Daniel Rösel include First Faculty of Medicine, Charles University in Prague & National Institutes of Health.
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The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells
TL;DR: This work outlines the signaling pathways involved in mesenchymal and amoeboid types of tumor cell motility and summarizes the molecular mechanisms that are involved in transitions between them and focuses on the Rho family of small GTPases that regulate the cytoskeleton-dependent processes taking place during the cell migration.
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Migrastatics—Anti-metastatic and Anti-invasion Drugs: Promises and Challenges
Aneta Gandalovičová,Daniel Rösel,Michael Fernandes,Pavel Veselý,Petr Heneberg,Vladimír Čermák,Luboš Petruželka,Sunil Kumar,Victoria Sanz-Moreno,Jan Brábek +9 more
TL;DR: The term ‘migrastatics’ is coined for drugs interfering with all modes of cancer cell invasion and metastasis, to distinguish this class from conventional cytostatic drugs, which are mainly directed against cell proliferation.
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The role of the tissue microenvironment in the regulation of cancer cell motility and invasion.
TL;DR: How the structural and biomechanical properties of extracellular matrix and surrounding cells such as endothelial cells influence cancer cell motility and invasion is discussed.
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Contractile forces in tumor cell migration.
TL;DR: Evidence indicating that tumor cell invasiveness is associated with increased contractile force generation is discussed, and recently developed biophysical tools are described, including 2-D and 3-D traction microscopy to measure contractile forces of cells.
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Vimentin Intermediate Filaments as Potential Target for Cancer Treatment.
Katerina Strouhalova,Magdalena Přechová,Aneta Gandalovičová,Jan Brábek,Martin Gregor,Daniel Rösel +5 more
TL;DR: The role of vimentsin intermediate filaments in cancer cell migration, cell adhesion structures, and metastasis formation is described and the potential for targeting vimentin in cancer treatment and the development of drugs targeting vimentalin will be reviewed.