▪ Abstract The prefrontal cortex has long been suspected to play an important role in cognitive control, in the ability to orchestrate thought and action in accordance with internal goals. Its neural basis, however, has remained a mystery. Here, we propose that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task. We review neurophysiological, neurobiological, neuroimaging, and computational studies that support this theory and discuss its implications as well as further issues to be addressed

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An integrative theory of prefrontal cortex function

I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Principles of Neural Science

Erik Eriksen is a remarkable individual. He has no college degrees yet is Professor of Human Development at Harvard University. He came to psychology via art, which explains why the reader will find him painting contexts and backgrounds rather than stating dull facts and concepts. He has been a training psychoanalyst for many years as well as a perceptive observer of cultural and social settings and their effect on growing up. This is not just a book on childhood. It is a panorama of our society. Anxiety in young children, apathy in American Indians, confusion in veterans of war, and arrogance in young Nazis are scrutinized under the psychoanalytic magnifying glass. The material is well written and devoid of technical jargon. The theme of the volume is that it is human to have a long childhood which will leave a lifelong residue of emotional immaturity in man. Primitive groups and

Childhood and Society.

In 1974 an article appeared in Science magazine with the dry-sounding title “Judgment Under Uncertainty: Heuristics and Biases” by a pair of psychologists who were not well known outside their discipline of decision theory. In it Amos Tversky and Daniel Kahneman introduced the world to Prospect Theory, which mapped out how humans actually behave when faced with decisions about gains and losses, in contrast to how economists assumed that people behave. Prospect Theory turned Economics on its head by demonstrating through a series of ingenious experiments that people are much more concerned with losses than they are with gains, and that framing a choice from one perspective or the other will result in decisions that are exactly the opposite of each other, even if the outcomes are monetarily the same. Prospect Theory led cognitive psychology in a new direction that began to uncover other human biases in thinking that are probably not learned but are part of our brain’s wiring.

Thinking fast and slow.

The author systematically examines one of the important issues of information — establishing the market price. He introduces the concept of «search» — where a buyer wanting to get a better price, is forced to question sellers. The article deals with various aspects of finding the necessary information.

Economics of Information

Selective information processing in neural networks is studied through computer simulations of Pavlovian conditioning data. The model reproduces properties of blocking, inverted-U in learning as a function of interstimulus interval, anticipatory conditioned responses, secondary reinforcement, attentional focusing by conditioned motivational feedback, and limited capacity short-term memory processing. Conditioning occurs from sensory to drive representations (conditioned reinforcer learning), from drive to sensory representations (incentive motivational learning), and from sensory to motor representations (habit learning).The conditionable pathwas contain long-term memory traces that obey a non-Hebbian associative law. The neural model embodies a solution to two key design problems of conditioning, the synchronization and persistence problems. This model of vertebrate learning is compared with data and models of invertebrate learning. Predictions derived from models of vertebrate learning are compared with data about invertebrate learning, including data from Aplysia about facilitator neurons and data from Hermissenda about voltage-dependent Ca(2+) currents. A prediction is stated about classical conditioning in all species, called the secondary conditioning alternative, and if confirmed would constitute an evolutionary invariant of learning.

Neural dynamics of attentionally modulated Pavlovian conditioning: blocking, interstimulus interval, and secondary reinforcement

From the Publisher:
This thoroughly and thoughtfully revised edition makes the principles and the details of neural network modeling accessible to cognitive scientists of all varieties as well as other scholars interested in these models." "Features of the second edition include: a new section on spatiotemporal pattern processing; coverage of ARTMAP networks (the supervised version of adaptive resonance networks) and recurrent back-propagation networks; a vastly expanded section on models of specific brain areas, such as the cerebellum, hippocampus, basal ganglia, and visual and motor cortex; and up-to-date coverage of applications of neural networks in areas such as combinational optimization and knowledge representation.

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Introduction to Neural and Cognitive Modeling

Modeling some effects of frontal lobe damage—novelty and perseveration

In industrial process control, there may be multiple performance objectives, depending on salient features of the input-output data. Aiming at this situation, this paper proposes multiple actor-critic structures to obtain the optimal control via input-output data for unknown nonlinear systems. The shunting inhibitory artificial neural network (SIANN) is used to classify the input-output data into one of several categories. Different performance measure functions may be defined for disparate categories. The approximate dynamic programming algorithm, which contains model module, critic network, and action network, is used to establish the optimal control in each category. A recurrent neural network (RNN) model is used to reconstruct the unknown system dynamics using input-output data. NNs are used to approximate the critic and action networks, respectively. It is proven that the model error and the closed unknown system are uniformly ultimately bounded. Simulation results demonstrate the performance of the proposed optimal control scheme for the unknown nonlinear system.

Multiple Actor-Critic Structures for Continuous-Time Optimal Control Using Input-Output Data

There is ample evidence that humans (and other pri- mates) possess a knowledge instinct—a biologically driven impulse to make coherent sense of the world at the highest level possible. Yet behavioral decision-making data suggest a contrary biological drive to minimize cognitive effort by solving problems using simplifying heuristics. Individuals differ, and the same person varies over time, in the strength of the knowledge instinct. Neuroimaging studies sug- gest which brain regions might mediate the balance between knowl- edge expansion and heuristic simplification. One region implicated in primary emotional experience is more activated in individuals who use primitive heuristics, whereas two areas of the cortex are more activated in individuals with a strong knowledge drive: one region implicated in detecting risk or conflict and another implicated in generating creative ideas. Knowledge maximization and effort mini- mization are both evolutionary adaptations, and both are valuable in different contexts. Effort minimization helps us make minor and rou- tine decisions efficiently, whereas knowledge maximization connects us to the beautiful, to the sublime, and to our highest aspirations. We relate the opposition between the knowledge instinct and heuristics to the biblical story of the fall, and argue that the causal scientific worldview is mathematically equivalent to teleological arguments from final causes. Elements of a scientific program are formulated to ad- dress unresolved issues.

Daniel S. Levine

Papers

Neural dynamics of attentionally modulated Pavlovian conditioning: blocking, interstimulus interval, and secondary reinforcement

Introduction to Neural and Cognitive Modeling

Modeling some effects of frontal lobe damage—novelty and perseveration

Multiple Actor-Critic Structures for Continuous-Time Optimal Control Using Input-Output Data

Simplifying heuristics versus careful thinking: Scientific analysis of millennial spiritual issues