Daniel S. Schmidt

TL;DR: A large-scale network integration of publicly available human blood transcriptomes and systems-scale databases in specific biological contexts revealed distinct transcriptional signatures of antibody responses to different classes of vaccines, which provided key insights into primary viral, protein recall and anti-polysaccharide responses.

TL;DR: The Centers for Disease Control and Prevention developed, optimized, and rapidly qualified an enzyme-linked immunosorbent assay (ELISA) for immunoglobulin G (IgG) antibodies to Bacillus anthracis protective antigen (PA) in human serum that proved valuable for the confirmation of cases of cutaneous and inhalational anthrax and evaluation of patients in whom the diagnosis of anthrax was being considered.

TL;DR: Anti-PA IgG is an important diagnostic marker of anthrax, a predictor of serum anti-toxin activity, and a marker of immunological memory against anthrax.

TL;DR: Sufficient quantity of this new preparation of 007sp is available such that, with judicious use, it should be available for at least 25 years.

TL;DR: The TNA assay was adapted and redesigned to establish a unifying, standardized, quantitative and validated technology platform for LTx neutralization in the J774A.1 murine cell line, demonstrating high precision, consistent accuracy and no detectable assay drift.