Carl W. Davis

TL;DR: A large-scale network integration of publicly available human blood transcriptomes and systems-scale databases in specific biological contexts revealed distinct transcriptional signatures of antibody responses to different classes of vaccines, which provided key insights into primary viral, protein recall and anti-polysaccharide responses.

TL;DR: A cross-sectional study of antibody responses to the receptor-binding domain (RBD) of the spike protein and virus neutralization activity in a cohort of 44 hospitalized COVID-19 patients, which has implications for understanding protective immunity against SARS-CoV-2, therapeutic use of immune plasma, and development of much-needed vaccines.

TL;DR: Epic repression of naive-associated genes in effector CD8 T cells can be reversed in cells that develop into long-lived memory T cells while key effector genes remain demethylated, demonstrating thatMemory T cells arise from a subset of fate-permissive effector T cells.

TL;DR: The phenotype and transcriptional program of a subset of antigen-specific B cells, which are called 'activated B cells' (ABCs), that were distinct from ASCs and were committed to the MBC lineage are defined.

TL;DR: Sustained immune activation after the virus was cleared from the plasma is found, observed most strikingly in the persistence of activated CD8 T cells, even 1 mo after the patients’ discharge from the hospital, suggesting continued antigen stimulation after resolution of the disease.