G
George M. Carlone
Researcher at Centers for Disease Control and Prevention
Publications - 135
Citations - 9542
George M. Carlone is an academic researcher from Centers for Disease Control and Prevention. The author has contributed to research in topics: Antibody & Vaccination. The author has an hindex of 54, co-authored 135 publications receiving 9170 citations. Previous affiliations of George M. Carlone include National Center for Immunization and Respiratory Diseases.
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Journal ArticleDOI
Molecular signatures of antibody responses derived from a systems biology study of five human vaccines
Shuzhao Li,Nadine Rouphael,Sai Duraisingham,Sandra Romero-Steiner,Scott R. Presnell,Carl W. Davis,Daniel S. Schmidt,Scott E. Johnson,Andrea Milton,Gowrisankar Rajam,Sudhir Pai Kasturi,George M. Carlone,Charlie Quinn,Damien Chaussabel,A. Karolina Palucka,Mark J. Mulligan,Rafi Ahmed,David S. Stephens,Helder I. Nakaya,Bali Pulendran +19 more
TL;DR: A large-scale network integration of publicly available human blood transcriptomes and systems-scale databases in specific biological contexts revealed distinct transcriptional signatures of antibody responses to different classes of vaccines, which provided key insights into primary viral, protein recall and anti-polysaccharide responses.
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Standardizing Chlamydia pneumoniae assays : Recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada)
Scott F. Dowell,Rosanna W. Peeling,Jens Boman,George M. Carlone,Barry S. Fields,Jeannette Guarner,Margaret R. Hammerschlag,Lisa A. Jackson,Cho-Chou Kuo,Matthias Maass,Trudy O. Messmer,Deborah F. Talkington,Maria Lucia Tondella,Sherif R. Zaki +13 more
TL;DR: Serological testing, culture, DNA amplification, and tissue diagnostics are reviewed, and standardized definitions for "acute infection" and "past exposure" are proposed, and the use of single immunoglobulin G titers for determining acute infection and IgA for determining chronic infection are discouraged.
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Standardization and a multilaboratory comparison of Neisseria meningitidis serogroup A and C serum bactericidal assays. The Multilaboratory Study Group.
Susan E. Maslanka,Linda L. Gheesling,Daniel E. Libutti,Kimberley B. J. Donaldson,H S Harakeh,Janet K. Dykes,F F Arhin,S J Devi,C E Frasch,Jyh-Hsiung Huang,P Kriz-Kuzemenska,R D Lemmon,M Lorange,C C Peeters,Sally A. Quataert,J Y Tai,George M. Carlone +16 more
TL;DR: The standardized SBA was reliable in all laboratories regardless of experience in performing SBAs, and will facilitate interlaboratory comparisons of the functional antibody produced in response to current or developing serogroup A and C meningococcal vaccines.
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Standardization of an opsonophagocytic assay for the measurement of functional antibody activity against Streptococcus pneumoniae using differentiated HL-60 cells.
Sandra Romero-Steiner,Daniel E. Libutti,Lorna B. Pais,Janet K. Dykes,Porter Anderson,John C. Whitin,Harry L. Keyserling,George M. Carlone +7 more
TL;DR: This standardized assay, in combination with the standardized ELISA, can be used to evaluate current and developing pneumococcal vaccines, in which functional opsonophagocytic antibody activity may correlate with protection against pneumococCal disease.
Journal ArticleDOI
Enzyme-linked immunosorbent assay for quantitation of human antibodies to pneumococcal polysaccharides.
Catherine M. Wernette,Carl E. Frasch,Dace V. Madore,George M. Carlone,David Goldblatt,Brian D. Plikaytis,William H. Benjamin,Sally A. Quataert,Steve Hildreth,Daniel J. Sikkema,Helena Käyhty,Ingileif Jonsdottir,Moon H. Nahm +12 more
TL;DR: Streptococcus pneumoniae is a major human pathogen causing pneumonia, sepsis, meningitis, and otitis media, and elderly adults because their immune systems are either unprepared or unable to respond effectively to it.