D
Daniel Sypniewski
Researcher at Medical University of Silesia
Publications - 29
Citations - 228
Daniel Sypniewski is an academic researcher from Medical University of Silesia. The author has contributed to research in topics: Cancer & Gene expression. The author has an hindex of 7, co-authored 29 publications receiving 189 citations.
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Journal ArticleDOI
Gene expression and activity of antioxidant enzymes in the blood cells of workers who were occupationally exposed to lead.
Aleksandra Kasperczyk,Grzegorz Machnik,Michał Dobrakowski,Daniel Sypniewski,Ewa Birkner,Sławomir Kasperczyk +5 more
TL;DR: It is concluded that lead has a significant influence not only on the activities of antioxidant enzymes but also on the dose-dependent expression in their genes.
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Morin decreases galectin-3 expression and sensitizes ovarian cancer cells to cisplatin.
TL;DR: It is demonstrated that morin possess antitumor activity against TOV-21G and SK-OV-3 ovarian cancer cells by reducing cell viability and proliferation as well as increasing the induction of apoptosis.
Journal Article
Distribution of porcine endogenous retroviruses (PERVs) DNA in organs of a domestic pig.
Daniel Sypniewski,Grzegorz Machnik,Urszula Mazurek,Tadeusz Wilczok,Z. Smorag,J. Jura,Barbara Gajda +6 more
TL;DR: It is concluded that kidney is potentially the biggest PERV reservoir which makes it the organ of particular concern in xenotransplantation, and it is possible to monitor pig herds for individuals with the lowest PERV DNA prevalence, especially lacking PERV-C, and perhaps with only defective PERV proviruses that are unable to express functional RNA.
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MiR-424-3p suppresses galectin-3 expression and sensitizes ovarian cancer cells to cisplatin.
TL;DR: It is demonstrated that miR-424-3p mimic effectively transfects into SK-OV-3 and TOV-21G ovarian cancer cells in which it significantly suppresses the expression of galectin-3 at the protein level, but not at the mRNA level.
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Contribution of reactive oxygen species to the anticancer activity of aminoalkanol derivatives of xanthone
Daniel Sypniewski,Natalia Szkaradek,Tomasz Loch,Anna M. Waszkielewicz,Agnieszka Gunia-Krzyżak,Daria Matczyńska,Dagna Sołtysik,Henryk Marona,Ilona Bednarek +8 more
TL;DR: It is demonstrated that novel aminoalkanol xanthones mediated their anticancer activity primarily through ROS elevation and enhanced oxidative stress, which led to mitochondrial cell death stimulation; this mechanism was similar to the activity of gambogic acid.