Showing papers by "Daniel Tranchina published in 2002"

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Journal Article•DOI•

Hypermutation in Shark Immunoglobulin Light Chain Genes Results in Contiguous Substitutions

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Susan S. Lee¹, Daniel Tranchina², Yuko Ohta³, Martin F. Flajnik³, Ellen Hsu¹ - Show less +1 more•Institutions (3)

State University of New York System¹, Courant Institute of Mathematical Sciences², University of Maryland, Baltimore³

01 Apr 2002-Immunity

TL;DR: Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes that suggest this is one of several pathways of hypermutation diversifying shark antigen-receptor genes that coevolved with or preceded gene rearrangement.

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96 citations