Showing papers in "Immunity in 2002"

TL;DR: A novel diphtheria toxin-based system that allows the inducible, short-term ablation of dendritic cells (DC) in vivo is reported and it is shown that in vivo DC are required to cross-prime CTL precursors.

TL;DR: A number of genes that antagonize signaling, including members of the SOCS family, may contribute to their anergic phenotype and GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset.

TL;DR: A new heterodimeric cytokine termed IL-27 is described that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL- 12p35-related polypeptide and drives rapid clonal expansion of naive but not memory CD4(+) T cells.

TL;DR: It is shown that CD28 costimulation functions to increase glycolytic flux, allowing T cells to anticipate energetic and biosynthetic needs associated with a sustained response.

TL;DR: It is established that expression of Delta-like-1 on stromal cells provides key signals for the induction of T cell lineage commitment, stage-specific progenitor expansion, TCR gene rearrangement, and T cell differentiation in the absence of a thymus.

TL;DR: It is found that contact, delayed-type, and airway hypersensitivity responses, as well as T-dependent antibody production, were significantly reduced in the mutant mice, while IL-17 deficiency of donor T cells did not affect acute graft-versus-host reaction.

TL;DR: These findings suggest that Blimp-1 promotes plasmacytic differentiation by extinguishing gene expression important for B cell receptor signaling, germinal center B cell function, and proliferation while allowing expression of important plasma cell genes such as XBP-1.

TL;DR: This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions.

TL;DR: These complexes on activated monocytes present IL-15 in trans to target cells such as CD8 + T cells that express only IL-2/15Rβ and γc upon cell-cell interaction and contribute to the long survival of T cells expressing IL- 15Rα afterIL-15 withdrawal.

TL;DR: The lymphotoxin-beta receptor (LTbetaR) plays critical roles in inflammation and lymphoid organogenesis through activation of NF-kappaB, which requires NIK and IKKalpha for activation and the induction by LTbetaR ligation of chemokines and cytokines involved in lymphoids organogenesis.

TL;DR: The results suggest that TLR3 and TLR4 have evolutionarily diverged from other TLRs to activate IRF3, which mediates a specific gene program responsible for innate antiviral responses.

TL;DR: Observations indicate that the essential function of the IL-2/IL-2R system primarily lies at the level of the production of CD4(+)CD25(+) regulatory T cells.

TL;DR: It is suggested that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response.

TL;DR: An important role for epithelial cells in controlling homeostatic lymphocyte trafficking, including the localization of cutaneous and intestinal memory T cells, and of IgA plasma cells is highlighted.

TL;DR: It is shown that blood-derived neutrophil granulocytes and CD11c(lo) immature dendritic cells (DC) are the primary cells that efficiently capture and transport particulate bacteria to the spleen.

TL;DR: SOCS-1 is suggested as an essential, negative regulator in LPS responses that protects the host from harmful overresponses to LPS and may provide new insight into the endotoxin-induced fatal syndrome that occasionally occurs following infection.

TL;DR: It is observed that cross-linking of NKG2D directly stimulates NK cells and activated macrophages and costimulates activated CD8(+) T cells, and plays a substantial role in natural killing.

TL;DR: A cellular mechanism underlying an experimental colitis that may explain the pathogenesis of ulcerative colitis is described, since NK-T cells are the source of the IL-13, since they produce IL- 13 upon stimulation by alpha-galactosylceramide, anNK-T cell-specific antigen.

TL;DR: It is shown that the suppressor of cytokine-signaling-1 (SOCS1/JAB) is rapidly induced by LPS and negatively regulates LPS signaling, which directly suppresses TLR4 signaling and modulates innate immunity.

TL;DR: The results indicate that B7-1 markedly favors CTLA-4 over CD28 engagement, whereas B71 exhibits much less bias, and is proposed to account for their overlapping but distinct effects on T cell responses.

TL;DR: The data suggest that interaction of TL1A with DR3 promotes T cell expansion during an immune response, whereas TR6 has an opposing effect.

TL;DR: Comparison with wild-type embryos showed that the distribution of HSCs among these various cell populations is sensitive to Runx1 dosage, which provides the first morphological description of embryonic H SCs and contribute new insight into their cellular origin.

TL;DR: The death of superantigen-stimulated T cells in vivo is mediated by Bim and may be modulated by a decrease in Bcl-2, which is also found to be resistant to SEB-induced deletion.

TL;DR: It is shown that DC-SIGN mediates rapid internalization of intact HIV into a low pH nonlysosomal compartment and reduces viral uptake and abrogated the trans-enhancement of T cell infection.

TL;DR: Optical transparency of zebrafish embryos is exploited to image the events of M. marinum infection in vivo and shows how infection can redirect normal embryonic macrophage migration, even recruiting macrophages seemingly committed to their developmentally dictated tissue sites.

TL;DR: It is reported that scavenger receptors are the main HSP binding structures on human dendritic cells and LOX-1 is identified as one of these molecules that is a promising target for cancer immunotherapy.

TL;DR: It is shown that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52 and inhibiting the BR3-BAFF interaction has therapeutic ramifications, and the ligand binding interface of BR3 was investigated and found to reside within a 26 residue core domain.

TL;DR: It is demonstrated that CTLA-4 has several unique trafficking properties that may regulate its ability to attenuate a T cell response, and accumulation at the immunological synapse is proportional to the strength of the TCR signal, suggesting that cells receiving stronger stimuli are more susceptible to CTla-4-mediated inhibition.

TL;DR: In mice lacking the chemokine, CXCL13, B1 cells are deficient in peritoneal and pleural cavities but not in spleen, providing insight into the mechanism of B1 cell homing and establishing a critical role for B1cell compartmentalization in the production of natural antibodies and for body cavity immunity.

TL;DR: Early lymphocyte progenitors (ELP) are distinct from stem cells, previously described prolymphocytes, or progenitor corresponding to other blood cell lineages, as well as indicating that distinctive early lymphocyte characteristics are not synchronously acquired.