P
Paolo Meda
Researcher at University of Geneva
Publications - 272
Citations - 18732
Paolo Meda is an academic researcher from University of Geneva. The author has contributed to research in topics: Insulin & Connexin. The author has an hindex of 74, co-authored 270 publications receiving 17677 citations. Previous affiliations of Paolo Meda include Carnegie Mellon University & University of Dundee.
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Journal ArticleDOI
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.
TL;DR: New insulin-secreting cell lines established from cells isolated from an x-ray-induced rat transplantable insulinoma indicate that INS-1 cells have remained stable and retain a high degree of differentiation which should make them a suitable model for studying various aspects of beta-cell function.
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The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo
Abigail Woodfin,Mathieu-Benoit Voisin,Martina Beyrau,Bartomeu Colom,Dorothée Caille,Frantzeska-Maria Diapouli,Gerard B. Nash,Triantafyllos Chavakis,Steven M. Albelda,G. Ed Rainger,Paolo Meda,Beat A. Imhof,Sussan Nourshargh +12 more
TL;DR: The results identify JAM-C as a key regulator of polarized neutrophil TEM in vivo and suggest that reverse TEM of neutrophils can contribute to the dissemination of systemic inflammation.
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Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization
Sylvie Montessuit,Syam Prakash Somasekharan,Oihana Terrones,Safa Lucken-Ardjomande,Sébastien Herzig,Robert Schwarzenbacher,Dietmar J. Manstein,Ella Bossy-Wetzel,Gorka Basañez,Paolo Meda,Jean-Claude Martinou +10 more
TL;DR: It is shown that Drp1 stimulates tBid-induced Bax oligomerization and cytochrome c release by promoting tethering and hemifusion of membranes in vitro by exploiting arginine 247 and the presence of cardiolipin in membranes.
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Production of Chemokines by Perivascular Adipose Tissue: A Role in the Pathogenesis of Atherosclerosis?
Elvire Henrichot,Cristiana E. Juge-Aubry,Agnès Pernin,Jean-Claude Pache,Valdimir Velebit,Jean-Michel Dayer,Paolo Meda,Carlo Chizzolini,Christoph A. Meier +8 more
TL;DR: It is proposed that pWAT might contribute to the progression of obesity-associated atherosclerosis, and the accumulation of macrophages and T cells at the interface between pWat and the adventitia of human atherosclerotic aortas may reflect this prochemotactic activity of pW AT.
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Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release.
Magalie A. Ravier,Martin Güldenagel,Anne Charollais,Asllan Gjinovci,Dorothée Caille,Goran Söhl,Claes B. Wollheim,Klaus Willecke,Jean-Claude Henquin,Paolo Meda +9 more
TL;DR: Data show that Cx36-dependent signaling is essential for the proper functioning of beta-cells, particularly for the pulsatility of [Ca(2+)](i) and insulin secretion during glucose stimulation.