F
Ferdinando Nicoletti
Researcher at Sapienza University of Rome
Publications - 834
Citations - 40870
Ferdinando Nicoletti is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Metabotropic glutamate receptor & Glutamate receptor. The author has an hindex of 93, co-authored 794 publications receiving 36770 citations. Previous affiliations of Ferdinando Nicoletti include University of Perugia & University of Catania.
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Journal ArticleDOI
Metabotropic glutamate receptors: From the workbench to the bedside
Ferdinando Nicoletti,Joël Bockaert,Graham L. Collingridge,PJ Conn,Francesco Ferraguti,Darryle D. Schoepp,Jarda T. Wroblewski,Jean-Philippe Pin +7 more
TL;DR: This review moves from those nostalgic times to the most recent advances in the physiology and pharmacology of mGlu receptors, and highlights the role of individual mGLU receptor subtypes in the pathophysiology of human disorders.
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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
Linda S. Steelman,William H. Chappell,Stephen L. Abrams,C. Ruth Kempf,Jacquelyn M. Long,Piotr Laidler,Sanja Mijatović,Danijela Maksimović-Ivanić,Franca Stivala,Maria Clorinda Mazzarino,Marco Donia,Paolo Fagone,Graziella Malaponte,Ferdinando Nicoletti,Massimo Libra,Michele Milella,Agostino Tafuri,Antonio Bonati,Jörg Bäsecke,Lucio Cocco,Camilla Evangelisti,Alberto M. Martelli,Giuseppe Montalto,Melchiorre Cervello,James A. McCubrey +24 more
TL;DR: The functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli are discussed and the recently described roles of these pathways in cancer stem cells, cellular senescence and aging are evaluated.
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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
William H. Chappell,Linda S. Steelman,Jacquelyn M. Long,Ruth C. Kempf,Stephen L. Abrams,Richard A. Franklin,Jörg Bäsecke,Franca Stivala,Marco Donia,Paolo Fagone,Graziella Malaponte,Maria Clorinda Mazzarino,Ferdinando Nicoletti,Massimo Libra,Danijela Maksimović-Ivanić,Sanja Mijatović,Giuseppe Montalto,Melchiorre Cervello,Piotr Laidler,Michele Milella,Agostino Tafuri,Antonio Bonati,Camilla Evangelisti,Lucio Cocco,Alberto M. Martelli,James A. McCubrey +25 more
TL;DR: This review will evaluate more recently described potential uses of MEK, PI3K, Akt and mTOR inhibitors in the proliferation of malignant cells, suppression of CICs, cellular senescence and prevention of aging.
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Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
Francesco Fornai,Oliver M. Schlüter,Paola Lenzi,Marco Gesi,Riccardo Ruffoli,Michela Ferrucci,Gloria Lazzeri,Carla L. Busceti,Fabrizio Pontarelli,Giuseppe Battaglia,Antonio Pellegrini,Ferdinando Nicoletti,Stefano Ruggieri,Antonio Paparelli,Thomas C. Südhof +14 more
TL;DR: Continuous low-level exposure of mice to MPTP causes a Parkinson-like syndrome in an alpha-synuclein-dependent manner, and the inhibition of the ubiquitinproteasome system and the production of inclusion bodies were reduced.
Journal ArticleDOI
Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus.
Ferdinando Nicoletti,James L. Meek,Michael J. Iadarola,De-Maw Chuang,Bryan L. Roth,Erminio Costa +5 more
TL;DR: Ibotenate, a rigid structural analogue of glutamate, markedly enhances the hydrolysis of membrane inositol phospholipids, as reflected by the stimulation of [3H]inositol monophosphate formation in rat hippocampal slices prelabeled with [ 3H]Inositol and treated with Li+.