Danielle N. Gross

TL;DR: In obese or diabetic states, FoxO1-dependent gene expression promotes some of the deleterious characteristics associated with these conditions, including hyperglycemia and glucose intolerance, but under these same pathophysiological conditions,FoxO1 expression may help drive the expression of genes involved in combating oxidative stress, thereby preserving cellular function.

TL;DR: It is demonstrated that decorin causes a sustained down-regulation of the EGFR and acts as an autocrine and paracrine regulator of tumor growth and could be utilized as an effective anti-cancer agent.

TL;DR: A noncanonical Akt-independent, phosphoinositide-3 kinase (PI3K)-dependent pathway that regulates adipocyte lipolysis using restricted subcellular signaling is described that selectively alters the PKA phosphorylation of its major lipid droplet-associated substrate, perilipin.

TL;DR: Further clarification of the role of Foxo1 in insulinresponsive tissues will strengthen the understanding and allow us to better combat insulin resistance and diabetes mellitus.

TL;DR: The data suggest that p115 has an important and specific role in insulin-stimulated GlUT4 translocation, probably by way of tethering insulin-sensitive Glut4 vesicles at an as yet unknown intracellular site.