M
Morris J. Birnbaum
Researcher at Pfizer
Publications - 242
Citations - 46326
Morris J. Birnbaum is an academic researcher from Pfizer. The author has contributed to research in topics: Protein kinase B & Insulin. The author has an hindex of 101, co-authored 238 publications receiving 42889 citations. Previous affiliations of Morris J. Birnbaum include University of Tübingen & University of Pennsylvania.
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Journal ArticleDOI
Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt
Henryk Dudek,Sandeep Robert Datta,Thomas F. Franke,Morris J. Birnbaum,Ryoji Yao,Geoffrey M. Cooper,Rosalind A. Segal,David R. Kaplan,Michael E. Greenberg +8 more
TL;DR: Findings suggest that in the developing nervous system, Akt is a critical mediator of growth factor-induced neuronal survival.
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Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
Han Cho,James Mu,Jason K. Kim,Jason K. Kim,Joanne L. Thorvaldsen,Qingwei Chu,E. Bryan Crenshaw,Klaus H. Kaestner,Marisa S. Bartolomei,Gerald I. Shulman,Gerald I. Shulman,Morris J. Birnbaum +11 more
TL;DR: It is shown that mice deficient in Akt2 are impaired in the ability of insulin to lower blood glucose because of defects in the action of the hormone on liver and skeletal muscle, establishing Akt 2 as an essential gene in the maintenance of normal glucose homeostasis.
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AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Yasuhiko Minokoshi,Thierry Alquier,Noboru Furukawa,Young-Bum Kim,Anna Lee,Bingzhong Xue,James Mu,Fabienne Foufelle,Pascal Ferré,Morris J. Birnbaum,Bettina J. Stuck,Barbara B. Kahn +11 more
TL;DR: Hypothalamic AMPK plays a critical role in hormonal and nutrient-derived anorexigenic and orexigenic signals and in energy balance, and inhibition of hypothalamic AM PK is necessary for leptin's effects on food intake and body weight, as constitutively active AMPK blocks these effects.
Journal ArticleDOI
AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint
Russell G. Jones,David R. Plas,Sara Kubek,Monica Buzzai,James Mu,Yang Xu,Morris J. Birnbaum,Craig B. Thompson +7 more
TL;DR: It is shown that proliferating mammalian cells have a cell-cycle checkpoint that responds to glucose availability and is regulated by AMP-activated protein kinase (AMPK), acell-cycle arrest that occurs despite continued amino acid availability and active mTOR.
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Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation
TL;DR: It is shown that Akt can regulate glucose uptake and metabolism and is expressed in 3T3-L1 adipocytes directed lipid but not glycogen synthesis.