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Danuta Zatorska
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 14
Citations - 453
Danuta Zatorska is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Stille reaction & Hsp90. The author has an hindex of 7, co-authored 14 publications receiving 430 citations. Previous affiliations of Danuta Zatorska include Kettering University.
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Journal ArticleDOI
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
Huazhong He,Danuta Zatorska,Joungnam Kim,Julia Aguirre,Laura Llauger,Yuhong She,Nian Wu,R.M. Immormino,Daniel T. Gewirth,Gabriela Chiosis +9 more
TL;DR: Hsp90 is a chaperone protein that allows cancer cells to tolerate the many components of dysregulated pathways as discussed by the authors, and its inactivation may result in targeting multiple molecular alterations and, thus, in...
Journal ArticleDOI
Measuring the Pharmacodynamic Effects of a Novel Hsp90 Inhibitor on HER2/neu Expression in Mice Using 89Zr-DFO-Trastuzumab
Jason P. Holland,Eloisi Caldas-Lopes,Vadim Divilov,Valerie A. Longo,Tony Taldone,Danuta Zatorska,Gabriela Chiosis,Jason S. Lewis +7 more
TL;DR: The results indicate that 89Zr-DFO-trastuzumab provides quantitative and highly-specific delineation of HER2/neu positive tumors, and has potential to be used to measure the efficacy of long-term treatment with Hsp90 inhibitors, like PU-H71, which display extended pharmacodynamic profiles.
Journal ArticleDOI
Design, synthesis, and evaluation of small molecule Hsp90 probes
Tony Taldone,Danuta Zatorska,Pallav D. Patel,Hongliang Zong,Anna Rodina,James H. Ahn,Kamalika Moulick,Monica L. Guzman,Gabriela Chiosis +8 more
TL;DR: The synthesis of chemical tools for three Hsp90 inhibitor classes will be useful for probing tumor-by-tumor the HSp90 complexes isolated by specific inhibitors, and will lead to better understanding of tumor specific molecular markers to aid in their clinical development.
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Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy.
Tony Taldone,Erica M. Gomes-DaGama,Hongliang Zong,Siddhartha Sen,Mary L. Alpaugh,Danuta Zatorska,Raul Alonso-Sabadell,Monica L. Guzman,Gabriela Chiosis +8 more
TL;DR: Fluorescent ligands for the heat shock protein 90 were synthesized containing either fluorescein isothiocyanate (FITC), 4-nitrobenzo[1,2,5]oxadiazole (NBD) or the red shifted dye sulforhodamine 101 (Texas Red) conjugated to PU-H71, suitable for fluorescence-activated flow cytometry and fluorescence microscopy.
Journal ArticleDOI
Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71
Tony Taldone,Danuta Zatorska,Stefan O. Ochiana,Peter Smith-Jones,Jacek Koziorowski,Mark Dunphy,Pat Zanzonico,Alexander Bolaender,Jason S. Lewis,Steven M. Larson,Gabriela Chiosis,Naga Vara Kishore Pillarsetty +11 more
TL;DR: The report sets the stage for the introduction of [(124)I]-PU-H71 as a potential non-invasive probe for understanding biodistribution and pharmacokinetics of PU-H 71 in living subjects using positron emission tomography imaging.