Daphne Deckers

TL;DR: It is suggested that the COG3895 domain is a common feature of a novel and widespread family of bacterial lysozyme inhibitors in gram-negative bacteria that may function as colonization or virulence factors in bacteria interacting with an animal host.

TL;DR: Results suggested the existence of a nonlytic mechanism of bactericidal action of lysozyme on Staphylococcus aureus and L. innocua, and this mechanism was further studied by means of a LIVE/DEAD viability stain based on a membrane-impermeant fluorescent dye.

TL;DR: Investigation of the role of Ivy in the resistance of E. coli to the bactericidal effect of lysozyme in the presence of outer-membrane-permeabilizing treatments suggests a possible function for Ivy as a host interaction factor in commensal and pathogenic E. bacteria.

TL;DR: Interestingly, strong inhibitory activity to HEWL is found in the chloroform/buffer extracts of Salmonella Typhimurium, and to LaL in the extracts of Pseudomonas aeruginosa, suggesting that other lysozyme inhibitors than Ivy exist and are probably widespread in gram-negative bacteria.

TL;DR: The results indicate that lysozyme inhibitors like Ivy promote bacterial survival or growth in particular lyso enzyme-rich secretions and suggest that they may promote the bacterial colonization of specific niches in the animal host.