Daria Krutauz

TL;DR: It is shown that acute oxidative stress caused by environmental insults or mitochondrial defects results in rapid disassembly of 26S proteasomes into intact 20S core and 19S regulatory particles, and polyubiquitinated substrates accumulate, mitochondrial networks fragment, and cellular reactive oxygen species (ROS) levels increase.

TL;DR: The dual functionality of Ddi1UBL, capable of binding both ubiquitin and proteasome, suggests an intriguing mechanism for Ddi 1 as a proteasomal shuttle.

TL;DR: In this article, the authors show that acute oxidative stress caused by environmental insults or mitochondrial defects results in rapid disassembly of 26S proteasomes into intact 20S core and 19S regulatory particles.

TL;DR: Functional redundancy of Rpn5 in budding yeast allows its participation and function in two distinct but structurally related PCI complexes: the proteasome lid and the CSN.

TL;DR: Proteasome-associated DUBs, Rpn11 and Ubp6, process long Lys11- or Lys63-linked polyUb more efficiently than Lys48 linkages, calling into question what constitutes an efficient signal for proteasome targeting versus proteolysis.