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Darren M. Brenner
Researcher at Northwestern University
Publications - 102
Citations - 1883
Darren M. Brenner is an academic researcher from Northwestern University. The author has contributed to research in topics: Irritable bowel syndrome & Medicine. The author has an hindex of 19, co-authored 71 publications receiving 1328 citations. Previous affiliations of Darren M. Brenner include University of Michigan & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
The Utility of Probiotics in the Treatment of Irritable Bowel Syndrome : A Systematic Review
TL;DR: Bifidobacterium infantis 35624 showed significant improvement in the composite score for abdominal pain/discomfort, bloating/distention, and/or bowel movement difficulty compared with placebo in two appropriately designed studies; there is inadequate data to comment on the efficacy of other probiotics.
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ACG Clinical Guideline: Management of Irritable Bowel Syndrome.
Brian E. Lacy,Mark Pimentel,Darren M. Brenner,William D. Chey,Laurie Keefer,Millie D. Long,Baha Moshiree +6 more
TL;DR: This first-ever American College of Gastroenterology clinical guideline for the management of IBS recommends that a positive diagnostic strategy as compared to a diagnostic strategy of exclusion be used to improve time to initiating appropriate therapy and recommends gut-directed psychotherapy to treat global IBS symptoms.
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Type, rather than number, of mental and physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome.
Jeffrey M. Lackner,Chang-Xing Ma,Laurie Keefer,Darren M. Brenner,Gregory D. Gudleski,Nikhil Satchidanand,Rebecca Firth,Michael D. Sitrin,Leonard A. Katz,Susan S. Krasner,Sarah Ballou,Bruce D. Naliboff,Emeran A. Mayer +12 more
TL;DR: Comorbidity type was more consistently and strongly associated with illness burden indicators than disease counts and specific comorbidities are associated with more severe symptoms of IBS.
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Improvement in Gastrointestinal Symptoms After Cognitive Behavior Therapy for Refractory Irritable Bowel Syndrome.
Jeffrey M. Lackner,James Jaccard,Laurie Keefer,Darren M. Brenner,Rebecca Firth,Gregory D. Gudleski,Frank A. Hamilton,Leonard A. Katz,Susan S. Krasner,Chang-Xing Ma,Christopher Radziwon,Michael D. Sitrin +11 more
TL;DR: In a randomized controlled trial, it is found that a primarily home-based version of CBT produced significant and sustained gastrointestinal symptom improvement for patients with IBS compared with education.
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Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and meta-analysis.
TL;DR: μ-Opioid receptor antagonists are safe and effective for the treatment of OIC and more data are required before the role of prucalopride or lubiprostone is clear.