Showing papers in "The American Journal of Gastroenterology in 2013"

TL;DR: As the diagnosis of AP is most often established by clinical symptoms and laboratory testing, contrast-enhanced computed tomography and/or magnetic resonance imaging of the pancreas should be reserved for patients in whom the diagnosis is unclear or who fail to improve clinically.

TL;DR: Treatment of patients with CDI should be stratified depending on whether they have mild-to-moderate, severe, or complicated disease, and a classification of disease severity is proposed to guide therapy that is useful for clinicians.

TL;DR: The following guideline will provide an overview of GERD and its presentation, and recommendations for the approach to diagnosis and management of this common and important disease.

TL;DR: Given the incomplete response of many patients to a GFD-free diet as well as the difficulty of adherence to the GFD over the long term, development of new effective therapies for symptom control and reversal of inflammation and organ damage are needed.

TL;DR: Recommendations developed by adult and pediatric gastroenterologists are provided for the evaluation and management of patients with eosinophilic–esophageal disorders.

TL;DR: Current approved treatment options, including metoclopramide and gastric electrical stimulation (GES), do not adequately address clinical need and attention should be given to the development of new effective therapies for symptomatic control.

TL;DR: FMT holds considerable promise as a therapy for recurrent CDI but well-designed, RCTs and long-term follow-up registries are still needed before this approach can be widely advocated.

TL;DR: This ACG guideline presents an evidence-based approach in patients with achalasia based on a comprehensive review of the pertinent evidence and examination of relevant published data.

TL;DR: The majority of IBS patients believe that certain food items are important triggers of their GI symptoms, and this is especially true for foods containing carbohydrates and fat, and also may be relevant for histamine-releasing food items and foods rich in biogenic amines.

TL;DR: Overall, eliminating diabetes/obesity could reduce the incidence of HCC more than the elimination of any other factor.

TL;DR: The organization of fiber types is outlined and the importance of assessing the fermentation characteristics of each fiber type when choosing a suitable strategy for patients is highlighted.

TL;DR: The presence of ATIs is associated with a significantly higher risk of loss of clinical response to IFX and lower serum IFX levels in patients with IBD.

TL;DR: This study highlights the value of characterizing temporally resolved microbiota dynamics for a better understanding of FMT efficacy and provides potentially useful diagnostic indicators for monitoring FMT success in the treatment of ulcerative colitis.

TL;DR: Anti-TNF therapy doubles the risk of opportunistic infections in inflammatory bowel disease patients, and underlines the importance of adherence to guidelines for their prevention and management.

TL;DR: Patients with low IFX trough levels at week 14 are at risk for ATI formation and IFX discontinuation, and it is recommended to measure IFX crest levels atWeek 14 and at time of LOR to rule out sustained ATI.

TL;DR: Combination of lactULose plus rifaximin is more effective than lactulose alone in the treatment of overt HE.

TL;DR: ADMs may modify the risk of HCC in patients with DM, especially in the Western population, however, the effect of each individual agent should be interpreted with caution owing to inherent cancer-modifying effect of the comparator group.

TL;DR: The incidence of celiac disease has continued to increase in the past decade in a North-American population and the relative frequency of classical CD among incident cases decreased over time between 2000 and 2010.

TL;DR: There is now an accumulating body of evidence that supports the notion that FODMAPs trigger gastrointestinal symptoms in patients with functional bowel disorders, and that a diet low in FodMAPs offers considerable symptom relief in the majority of patients who use it.

TL;DR: The Western Dietary Pattern is Prospectively Associated with Nonalcoholic Fatty Liver Disease in Adolescence as discussed by the authors, which is the most common cause of nonalcoholic liver disease in adolescents.

TL;DR: While symptoms did not improve and dietary compliance was problematic, there was substantial histologic improvement after 4 weeks on the elemental diet.

TL;DR: Although EoE was seen in nearly a quarter of patients with dysphagia, PPI-REE was almost as common, and accounted for over one-third of those with ≥15 eos/hpf, and none were significantly associated with disease status on multivariable analysis.

TL;DR: The long-term risk of metastasis after ER was mainly associated with the depth of invasion, and this risk should be taken into account when considering the indications for ER.

TL;DR: No evidence of a relationship between SI and GE was identified for different drugs used for the treatment of gastroparesis, and this finding questions the use of GE measurement to direct drug development for gastroparedis.

TL;DR: The treatment with thiopurines and anti-TNF-α drugs does not seem to increase the risk of complications during pregnancy and does seem to be safe for the newborn.

TL;DR: CSP is superior to CFP for the endoscopic removal of DCPs with regard to completeness of polypectomy and should be considered the primary method for endoscopic treatment of polyps in the 4–5-mm size range.

TL;DR: The highest risk for cancer in the first year after AIP diagnosis and absence of AIP relapse after successful treatment of the coexisting cancers suggest that AIP may develop as a paraneoplastic syndrome in some patients.

TL;DR: Lack of augmentation of smooth muscle contraction following MRS is associated with late postoperative dysphagia following antireflux surgery, suggesting that MRS responses could assess esophageal smooth muscle peristaltic reserve.

TL;DR: Machine-learning algorithms improve the accuracy of risk stratifying patients with cirrhosis and can be used to accurately identify patients at high-risk for developing HCC.

TL;DR: Risk of T-cell NHL is increased with T NF-α inhibitor use in combination with thiopurines but not with TNF-α inhibitors alone, and this risk was calculated using Fisher's exact test using 5-aminosalicylates as control drugs.