D
Darrin J. Bast
Researcher at University of Toronto
Publications - 32
Citations - 1973
Darrin J. Bast is an academic researcher from University of Toronto. The author has contributed to research in topics: Streptococcus pneumoniae & Streptococcus pyogenes. The author has an hindex of 18, co-authored 32 publications receiving 1934 citations. Previous affiliations of Darrin J. Bast include Mount Sinai Hospital, Toronto & Mount Sinai Hospital.
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Journal ArticleDOI
Resistance to Levofloxacin and Failure of Treatment of Pneumococcal Pneumonia
Ross J Davidson,Rodrigo B. Cavalcanti,James L. Brunton,Darrin J. Bast,Joyce C. S. de Azavedo,Pamela Kibsey,Christine Fleming,Donald E. Low +7 more
TL;DR: In these patients, the isolates of Streptococcus pneumoniae were resistant to levofloxacin, and in two of them the resistance appeared to have been acquired during the current course of treatment with fluoroquinolones.
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Genetic Locus for Streptolysin S Production by Group A Streptococcus
Victor Nizet,Bernard Beall,Darrin J. Bast,Vivekananda Datta,Laurie Kilburn,Donald E. Low,Joyce C. S. de Azavedo +6 more
TL;DR: Borgia et al. as mentioned in this paper used transposon mutagenesis, chromosomal walking steps, and data from the GAS genome sequencing project to identify a contiguous nine-gene locus (sagA to sagI) involved in SLS production.
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Description of Staphylococcus Serine Protease (ssp) Operon in Staphylococcus aureus and Nonpolar Inactivation of sspA-Encoded Serine Protease
TL;DR: It is concluded that SspA is required for maturation of SspB and plays a role in controlling autolytic activity but does not by itself exert a significant contribution to the development of tissue abscess infections.
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Streptolysin S and necrotising infections produced by group G streptococcus
Deepali Humar,Vivekananda Datta,Darrin J. Bast,Bernard Beall,Joyce C. S. de Azavedo,Victor Nizet +5 more
TL;DR: In this article, the authors found that β-haemolytic group G streptococcus was the sole microbial isolate from debrided necrotic tissue, and they used hybridisation, DNA sequencing, targeted mutagenesis, and complementation studies were used to establish the genetic basis for group G staphylococcus β-hemolytic activity.
Journal ArticleDOI
Fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae: contributions of type II topoisomerase mutations and efflux to levels of resistance.
Darrin J. Bast,Darrin J. Bast,Donald E. Low,Donald E. Low,C.L. Duncan,Laurie Kilburn,Lionel A. Mandell,Ross J. Davidson,Joyce C. S. de Azavedo,Joyce C. S. de Azavedo +9 more
TL;DR: Isolates with intermediate-level and high-level resistance harbored substitutions of Phe and Tyr for Ser-79 or Asn and Ala for Asp-83 in ParC and an additional substitution in GyrA which included either Glu-85-Lys (Gly) or Ser-81-Phe (Tyr).