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David A. Armstrong
Researcher at Dartmouth–Hitchcock Medical Center
Publications - 48
Citations - 2259
David A. Armstrong is an academic researcher from Dartmouth–Hitchcock Medical Center. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 25, co-authored 46 publications receiving 1839 citations. Previous affiliations of David A. Armstrong include Dartmouth College & United States Department of Veterans Affairs.
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The roles of DNA methylation of NR3C1 and 11β-HSD2 and exposure to maternal mood disorder in utero on newborn neurobehavior
TL;DR: The results support the fetal programming hypothesis and suggest that fetal adjustments to cues from the intrauterine environment, in this case an environment that could be characterized by increased exposure to maternal cortisol, may lead to poor neurodevelopmental outcomes.
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MicroRNA molecular profiling from matched tumor and bio-fluids in bladder cancer
TL;DR: MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma.
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Patterning in placental 11-B hydroxysteroid dehydrogenase methylation according to prenatal socioeconomic adversity.
Allison A. Appleton,David A. Armstrong,Corina Lesseur,Joyce S Lee,James F. Padbury,Barry M. Lester,Carmen J. Marsit +6 more
TL;DR: In this article, the authors examined the association between DNA methylation of the HSD11B2 promoter region in the placenta of 444 healthy term newborn infants and several markers of prenatal socioeconomic adversity: maternal education, poverty, dwelling crowding, tobacco use and cumulative risk.
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Genetic and epigenetic variation of the glucocorticoid receptor (NR3C1) in placenta and infant neurobehavior.
TL;DR: It is suggested that epigenetic alteration of the NR3C1 gene in the placentas of genetically susceptible infants can have impacts on neurodevelopment which may have lifelong impact on neurobehavioral and mental health outcomes.
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Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research
TL;DR: It is concluded that placenta, cord blood, and saliva cannot be used as a substitute for one another to evaluate DNA methylation at these loci during infancy, and each tissue has a unique epigenetic signature that likely reflects their differential functions.