Benjamin B. Green

TL;DR: MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma.

TL;DR: The potential for arsenic, even at levels commonly experienced in a U.S. population, to have effects on the DNA methylation status of specific genes in the placenta is demonstrated and thus supports a potentially novel mechanism for arsenic to affect long-term children’s health.

TL;DR: Gene ontology analysis suggested that those genes with variable methylation related to these outcomes are over-represented in biological pathways involved in brain development and placental physiology, supportive of the hypothesis for a key role of the placenta in neurobehavioral outcomes.

TL;DR: The comprehensive placental profiling of imprinted genes in a large birth cohort supports the importance of these genes for fetal growth and has the potential to be developed as a novel biomarker for postnatal health outcomes.

TL;DR: Results suggest that common variation in placental imprinted gene expression is linked to suboptimal performance on scales of neurological functioning as well as with increased signs of physiologic stress, highlighting the central importance of the control of expression of these genes in the placenta for neurobehavioral development.