D
David A. Eisner
Researcher at University of Manchester
Publications - 267
Citations - 14383
David A. Eisner is an academic researcher from University of Manchester. The author has contributed to research in topics: Ryanodine receptor & Calcium. The author has an hindex of 69, co-authored 256 publications receiving 13473 citations. Previous affiliations of David A. Eisner include University of Oxford & Research Triangle Park.
Papers
More filters
Journal ArticleDOI
The role of sarcolemmal Ca2+‐ATPase in the regulation of resting calcium concentration in rat ventricular myocytes
Ho Sook Choi,David A. Eisner +1 more
TL;DR: The results demonstrate the role of a carboxyeosin‐sensitive Ca2+‐ATPase in the control of resting [Ca2+]i and the reduction in [ Ca2-i following an increase in [Ca1-i], as well as in the absence of extracellular Na+, which is, in part, due to a increase in sarcoplasmic reticulum Ca2 + content.
Journal ArticleDOI
Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure.
Nathan Denham,Charles M. Pearman,Jessica L. Caldwell,George W.P. Madders,David A. Eisner,Andrew W. Trafford,Katharine M. Dibb +6 more
TL;DR: The latest evidence is presented showing a fundamental role for calcium in both the induction and maintenance of AF, and the effects of heart failure on atrial calcium handling that promote AF will be reviewed, including effects on both atrial myocytes and the pulmonary veins.
Journal ArticleDOI
What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis
TL;DR: The role of the Ryanodine Receptor (RyR) in cardiac inotropy and arrhythmogenesis is reviewed and it is shown that, due to compensatory changes of SR Ca content, simply making the RyR leaky does not produce Ca waves in the steady state and thatSR Ca content is critical in determining whether Ca waves occur.
Journal ArticleDOI
The dependence on heart rate of the human ventricular action potential duration
TL;DR: For the human electrocardiogram, the relationship between QT interval and heart rate was examined in conditions where theHeart rate was changed at different rates, similar to that seen for the relationships between action potential duration and stimulation rate in isolated pieces of mammalian ventricle.
Journal ArticleDOI
Simultaneous measurements of changes in sarcoplasmic reticulum and cytosolic [Ca2+] in rat uterine smooth muscle cells
TL;DR: These data show that it is possible to simultaneously measure SR and cytosolic [Ca2+], and to investigate their response to agonist application and spontaneous activity.