D
David A. Garcia
Researcher at University of Maryland, College Park
Publications - 14
Citations - 517
David A. Garcia is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Transcription factor & Dielectric. The author has an hindex of 7, co-authored 12 publications receiving 196 citations. Previous affiliations of David A. Garcia include National Institutes of Health & University of Los Andes.
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Journal ArticleDOI
Ultrahigh capacitive energy density in ion-bombarded relaxor ferroelectric films
Jieun Kim,Sahar Saremi,Megha Acharya,Gabriel Velarde,Eric Parsonnet,Patrick Donahue,Alexander Qualls,David A. Garcia,Lane W. Martin,Lane W. Martin +9 more
TL;DR: It is shown that high-energy ion bombardment improves the energy storage performance of relaxor ferroelectric thin films and suggests that postprocessing may be important for developing the next generation of capacitors.
Journal ArticleDOI
Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility
Diana A. Stavreva,David A. Garcia,Grégory Fettweis,Prabhakar R. Gudla,George Zaki,Vikas Soni,Andrew McGowan,Geneva Williams,Anh Huynh,Murali Palangat,R. Louis Schiltz,Thomas A. Johnson,Diego M. Presman,Matthew L. Ferguson,Gianluca Pegoraro,Arpita Upadhyaya,Gordon L. Hager +16 more
TL;DR: It is demonstrated that transcription factor (TF) nuclear mobility determines burst duration, whereas its bound fraction determines burst frequency, and a striking co-bursting pattern between TSs located at proximal and distal positions in the nucleus is uncovered.
Journal ArticleDOI
An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors.
David A. Garcia,David A. Garcia,Thomas A. Johnson,Diego M. Presman,Grégory Fettweis,Kaustubh Wagh,Kaustubh Wagh,Lorenzo Rinaldi,Diana A. Stavreva,Ville Paakinaho,Rikke A.M. Jensen,Rikke A.M. Jensen,Susanne Mandrup,Arpita Upadhyaya,Gordon L. Hager +14 more
TL;DR: In this article, the authors used single-molecule tracking and machine-learning-based classification to directly measure the nuclear mobility of the glucocorticoid receptor (GR) in live cells.
Journal ArticleDOI
Mechanical Regulation of Transcription: Recent Advances.
Kaustubh Wagh,Kaustubh Wagh,Momoko Ishikawa,David A. Garcia,David A. Garcia,Diana A. Stavreva,Arpita Upadhyaya,Gordon L. Hager +7 more
TL;DR: In this paper, the authors highlight the importance of mechanotransduction as one of the governing principles of cancer progression and emphasize the need to conduct further studies of the molecular mechanisms involved in sensing mechanical cues and coordinating transcriptional responses.
Journal ArticleDOI
Power-law behavior of transcription factor dynamics at the single-molecule level implies a continuum affinity model.
David A. Garcia,David A. Garcia,Grégory Fettweis,Diego M. Presman,Diego M. Presman,Ville Paakinaho,Ville Paakinaho,Christopher Jarzynski,Arpita Upadhyaya,Gordon L. Hager +9 more
TL;DR: In this article, the authors proposed a continuum of affinities model to explain transcription factor (TF) dynamics, which is consistent with complex interactions of TFs with multiple nuclear domains as well as binding and searching on the chromatin template.