Prabhakar R. Gudla

TL;DR: The ability of p8 to simultaneously anergize and cluster T cells, together with its induction of cellular conduits, secures virus propagation while avoiding the host's immune surveillance.

TL;DR: This work directly probed the relationship between nuclear positioning and gene activity by comparing the location of the active and inactive copies of a monoallelically expressed gene in single cell nuclei and shows that the functionally distinct alleles occupy differential radial positions within the cell nucleus and differentially associate with intranuclear compartments.

TL;DR: It is demonstrated that transcription factor (TF) nuclear mobility determines burst duration, whereas its bound fraction determines burst frequency, and a striking co-bursting pattern between TSs located at proximal and distal positions in the nucleus is uncovered.

TL;DR: In this paper, a quasi-genome-scale platform for observing synthesis and processing kinetics of single nascent RNA molecules in real time is established, and all observed genes show transcriptional bursting.

TL;DR: The existence of TCR microclusters prior to ligand binding in a state that is conducive for the initiation of downstream signaling could explain, in part, the rapid kinetics with which TCR signal transduction occurs.