D
David C. Hooper
Researcher at Harvard University
Publications - 289
Citations - 28620
David C. Hooper is an academic researcher from Harvard University. The author has contributed to research in topics: DNA gyrase & Topoisomerase IV. The author has an hindex of 80, co-authored 274 publications receiving 26064 citations. Previous affiliations of David C. Hooper include Albert Einstein College of Medicine & Lahey Hospital & Medical Center.
Papers
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Journal ArticleDOI
Hospital-Acquired Infections Due to Gram-Negative Bacteria
Anton Y. Peleg,David C. Hooper +1 more
TL;DR: What clinicians should know about hospital-acquired infections is updated to reflect the latest research on Gram-negative bacteria and antibiotic drug resistance.
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Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
Ari Robicsek,Jacob Strahilevitz,George A. Jacoby,Mark J. Macielag,Darren Abbanat,Chi Hye Park,Karen Bush,David C. Hooper +7 more
TL;DR: Reduced susceptibility to ciprofloxacin in clinical bacterial isolates conferred by a variant of the gene encoding aminoglycoside acetyltransferase AAC(6′)-Ib, first reported in 2003 and now widely disseminated is described.
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The worldwide emergence of plasmid-mediated quinolone resistance
TL;DR: Their insidious promotion of substantial resistance, their horizontal spread, and their co-selection with other resistance elements indicate that a more cautious approach to quinolone use and a reconsideration of clinical breakpoints are needed.
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Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy
Joseph W. Chow,Michael J. Fine,David M. Shlaes,John P. Quinn,David C. Hooper,Michaekl P. Johnson,Reuben Ramphal,Marilyn M. Wagener,Deborah K. Miyashiro,Victor L. Yu +9 more
TL;DR: More judicious use of third-generation cephalosporins may decrease the incidence of nosocomial multiresistant Enterobacter spp.
Journal ArticleDOI
Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat
TL;DR: The best-described form of PMQR is determined by the qnr group of genes, likely originating in aquatic organisms, which code for pentapeptide repeat proteins that reduce susceptibility to quinolones by protecting the complex of DNA and DNA gyrase or topoisomerase IV enzymes from the inhibitory effect of qu inolones.