D
David C. Myles
Researcher at Kosan Biosciences
Publications - 97
Citations - 2490
David C. Myles is an academic researcher from Kosan Biosciences. The author has contributed to research in topics: Discodermolide & Diene. The author has an hindex of 26, co-authored 96 publications receiving 2415 citations. Previous affiliations of David C. Myles include University of California, Los Angeles & National Institute of Standards and Technology.
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Journal ArticleDOI
Synthesis and biological activities of novel 17-aminogeldanamycin derivatives
Zong-Qiang Tian,Yaoquan Liu,Dan Zhang,Zhan Wang,Steven D. Dong,Christopher Carreras,Yiqing Zhou,Giulio Rastelli,Daniel V. Santi,David C. Myles +9 more
TL;DR: A library of over sixty 17-alkylamino-17-demethoxygeldanamycin analogs was prepared, and their affinity for Hsp90, ability to inhibit growth of SKBr3 mammalian cells, and in selected cases, water solubility were compared.
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Substrate specificity and carbohydrate synthesis using transketolase
TL;DR: A practical protocol for transketolase-catalyzed condensation of hydroxypyruvic acid with these aldehydes has been developed and used for the synthesis of four carbohydrates.
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Molecular Recognition on Functionalized Self-Assembled Monolayers of Alkanethiols on Gold
TL;DR: In this article, a system for probing molecular recognition events at organic interfaces using fluorescent receptors was described, formed from the bis(2,6-diaminopyridine) amide of isophthalic acid.
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Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis.
Wayne W. Poon,Robert J. Barkovich,Adam Y. Hsu,Adam Frankel,Peter T. Lee,Jennifer N. Shepherd,David C. Myles,Catherine F. Clarke +7 more
TL;DR: Results indicate that oneO-methyltransferase catalyzes both steps in Q biosynthesis in eukaryote and prokaryotes and thatQ biosynthesis is carried out within the matrix compartment of yeast mitochondria.
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Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis.
TL;DR: UbiG gene is able to restore respiration in the yeast coq3 mutant, provided ubiG is modified to contain a mitochondrial leader sequence, and the ability of UbiG to catalyze both O-methylation steps in E. coli was investigated.