Signaling Recognition Events with Fluorescent Sensors and Switches.

Sensitive optical biosensors for unlabeled targets: a review.

Organometallic chemistry on silicon and germanium surfaces.

Novel organic−inorganic hybrid mesoporous materials have been synthesized, in which organic and inorganic oxide moieties are distributed homogeneously at the molecular level in the framework, forming a covalently bonded network. They are highly ordered at the mesoscale, with two- and three-dimensional hexagonal symmetries and well-defined external morphologies. Nitrogen adsorption measurements show a uniform pore-size distribution with pore diameters of 31 and 27 A, and high surface areas of 750 and 1170 m2/g. The synthetic procedure to polymerize the organosilane monomer containing two trialkoxysilyl groups in the presence of surfactant can be applied to the synthesis of a variety of highly ordered organic−inorganic hybrid mesoporous materials.

http://dns2.asia.edu.tw/~ysho/YSHO-English/1000%20WC/PDF/J%20Ame%20Che%20Soc121,%209611.pdf

Novel Mesoporous Materials with a Uniform Distribution of Organic Groups and Inorganic Oxide in Their Frameworks

http://nathan.instras.com/documentDB/paper-69.pdf

Porous silicon: a quantum sponge structure for silicon based optoelectronics

A biosensor has been developed based on induced wavelength shifts in the Fabry-Perot fringes in the visible-light reflection spectrum of appropriately derivatized thin films of porous silicon semiconductors. Binding of molecules induced changes in the refractive index of the porous silicon. The validity and sensitivity of the system are demonstrated for small organic molecules (biotin and digoxigenin), 16-nucleotide DNA oligomers, and proteins (streptavidin and antibodies) at pico- and femtomolar analyte concentrations. The sensor is also highly effective for detecting single and multilayered molecular assemblies.

https://science.sciencemag.org/content/sci/278/5339/840.full.pdf

A Porous Silicon-Based Optical Interferometric Biosensor

We present in this paper that porous silicon can be used as a large surface area matrix as well as the transducer of biomolecular interactions. We report the fabrication of heavily doped p-type porous silicon with pore diameters that can be tuned, depending on the etching condition, from approximately 5 to 1200 nm. The structure and porosity of the matrixes were characterized by scanning force microscopy (SFM) and scanning electron microscopy (SEM), Brunnauer−Emmett−Teller nitrogen adsorption isotherms, and reflectance interference spectroscopy. The thin porous silicon layers are transparent to the visible region of the reflectance spectra due to their high porosity (80−90%) and are smooth enough to produce Fabry−Perot fringe patterns upon white light illumination. Porous silicon matrixes were modified by ozone oxidation, functionalized in the presence of (2-pyridyldithiopropionamidobutyl)dimethylmethoxysilane, reduced to unmask the sulfhydryl functionalities, and coupled to biotin through a disulfide-bon...

Macroporous p-Type Silicon Fabry−Perot Layers. Fabrication, Characterization, and Applications in Biosensing

The measurement of the wavelength shifts in the reflectometric interference spectra of a porous semiconductor substrate such as silicon, make possible the highly sensitive detection, identification and quantification of small analyte molecules. The sensor of the subject invention is effective in detecting multiple layers of biomolecular interactions, termed “cascade sensing”, including sensitive detection of small molecule recognition events that take place relatively far from the semiconductor surface.

Porous semiconductor-based optical interferometric sensor

A system for probing molecular recognition events at organic interfaces using fluorescent receptors is described. Receptors formed from the bis(2,6-diaminopyridine) amide of isophthalic acid are in...

Kianoush Motesharei

Papers

A Porous Silicon-Based Optical Interferometric Biosensor

Macroporous p-Type Silicon Fabry−Perot Layers. Fabrication, Characterization, and Applications in Biosensing

Porous semiconductor-based optical interferometric sensor

Molecular Recognition on Functionalized Self-Assembled Monolayers of Alkanethiols on Gold

Molecular Recognition in Membrane Mimics: A Fluorescence Probe