D
David Crews
Researcher at University of Texas at Austin
Publications - 419
Citations - 21165
David Crews is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Temperature-dependent sex determination & Estrogen. The author has an hindex of 77, co-authored 416 publications receiving 20336 citations. Previous affiliations of David Crews include Rockefeller University & University of North Texas.
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Journal ArticleDOI
Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling
Joseph W. Thornton,Joseph W. Thornton,Eleanor F. Need,Eleanor F. Need,David Crews,David Crews +5 more
TL;DR: These findings indicate that SRs are extremely ancient and widespread, having diversified from a primordial gene before the origin of bilaterally symmetric animals, and that this ancient receptor had estrogen receptor–like functionality.
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Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts.
TL;DR: Three distinct estrogen receptor subtypes are described: ERalpha, ERbeta, and a unique type, ERgamma, cloned from a teleost fish, the Atlantic croaker Micropogonias undulatus; the first identification of a third type of classical ER in vertebrate species.
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Transgenerational epigenetic imprints on mate preference.
David Crews,Andrea C. Gore,Timothy S. Hsu,Nygerma L. Dangleben,Michael J. Spinetta,Timothy J Schallert,Matthew D. Anway,Michael K. Skinner +7 more
TL;DR: Examination of mate preference in male and female rats whose progenitors had been treated with the antiandrogenic fungicide vinclozolin shows that females three generations removed from the exposure discriminate and prefer males who do not have a history of exposure, whereas similarly epigenetically imprinted males do not exhibit such a preference.
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PCBs as environmental estrogens: turtle sex determination as a biomarker of environmental contamination.
TL;DR: The estrogenic effect of some PCBs is demonstrated by reversing gonadal sex in a reptile species that exhibits temperature-dependent sex determination.
Journal ArticleDOI
Epigenetic transgenerational inheritance of altered stress responses
David Crews,Ross Gillette,Samuel V. Scarpino,Mohan Manikkam,Marina I. Savenkova,Michael K. Skinner +5 more
TL;DR: It is found that a single exposure to a common-use fungicide three generations removed alters the physiology, behavior, metabolic activity, and transcriptome in discrete brain nuclei in descendant males, causing them to respond differently to chronic restraint stress.