D
David D. Sabatini
Researcher at New York University
Publications - 122
Citations - 18170
David D. Sabatini is an academic researcher from New York University. The author has contributed to research in topics: Endoplasmic reticulum & Golgi apparatus. The author has an hindex of 59, co-authored 119 publications receiving 17814 citations. Previous affiliations of David D. Sabatini include Rockefeller University & Yale University.
Papers
More filters
Journal ArticleDOI
Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation.
TL;DR: A postfixation in osmium tetroxide, even after long periods of storage, developed an image that—notable in the case of glutaraldehyde—was largely indistinguishable from that of tissues fixed under optimal conditions with osmia tetroxides alone.
Journal ArticleDOI
Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival
Heather P. Harding,Huiqing Zeng,Yuhong Zhang,Rivka Jungries,Peter Chung,Heidi Plesken,David D. Sabatini,David Ron +7 more
TL;DR: Findings suggest a special role for translational control in protecting secretory cells from ER stress in diabetes mellitus and exocrine pancreatic insufficiency.
Journal ArticleDOI
Polarized monolayers formed by epithelial cells on a permeable and translucent support.
TL;DR: Measurements of Na+ permeability of electrical and tracer methods ruled out exchange diffusion as a mechanism for ion permeation and the lack of current saturation in the I/deltapsi curves does not support the involvement of carriers.
Journal ArticleDOI
Mechanisms for the incorporation of proteins in membranes and organelles.
TL;DR: Mechanisms for the transfer of newly synthesized polypeptides to their sites of function in different subcellular membranes and organelles are considered, and models in which specific features of the polypePTides serve as signals to direct them along selected sub cellular pathways to their final destination are discussed.
Journal ArticleDOI
Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes
Vincent F. Taelman,Radoslaw Dobrowolski,Jean-Louis Plouhinec,Luis C. Fuentealba,Peggy P. Vorwald,Iwona Gumper,David D. Sabatini,Edward M. De Robertis +7 more
TL;DR: It is reported that Wnt signaling triggers the sequestration of GSK3 from the cytosol into multivesicular bodies (MVBs), so that this enzyme becomes separated from its many cytosolic substrates.