Milton Adesnik

TL;DR: Mechanisms for the transfer of newly synthesized polypeptides to their sites of function in different subcellular membranes and organelles are considered, and models in which specific features of the polypePTides serve as signals to direct them along selected sub cellular pathways to their final destination are discussed.

TL;DR: A nomenclature for the P450 gene superfamily is proposed based on evolution, and recommendations include Roman numerals for distinct gene families, capital letters for subfamilies, and Arabic numeral for individual genes.

TL;DR: A modest revision of the initially proposed nomenclature of the P450 superfamily is described specifically for the human and mouse chromosomal loci, with the root symbol "CYP" for human ("Cyp" for mouse), denoting "cytochrome P450."

TL;DR: The incapacity of the constitutively active form of rab11 (Q70L) to inhibit recycling of molecules interiorized at 16 degreesC is consistent with their recycling taking place directly from sorting endosomes, in a process that does not require hydrolysis of GTP on rab11.

TL;DR: There is a fundamental difference in the process by which endocytic vesicles are formed at the two surfaces of polarized epithelial cells and that the integrity and/or the polymerization of actin filaments are required at the apical surface.