D
David E. Kuhl
Researcher at University of California, Los Angeles
Publications - 134
Citations - 18917
David E. Kuhl is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Emission computed tomography & Ictal. The author has an hindex of 65, co-authored 134 publications receiving 18635 citations. Previous affiliations of David E. Kuhl include National Institutes of Health.
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Journal ArticleDOI
Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method.
Michael E. Phelps,Michael E. Phelps,Sung-Cheng Huang,Sung-Cheng Huang,Edward J. Hoffman,Edward J. Hoffman,Carl Selin,Carl Selin,L. Sokoloff,L. Sokoloff,David E. Kuhl,David E. Kuhl +11 more
TL;DR: The data indicate that cerebral FDG‐6‐PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.
Journal ArticleDOI
The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man.
Martin Reivich,David E. Kuhl,Alfred P. Wolf,Joel H. Greenberg,Michael E. Phelps,T. Ido,V Casella,Joanna S. Fowler,Eric A. Hoffman,Abass Alavi,Peter M. Som,L. Sokoloff +11 more
TL;DR: A mathematical model and derived operational equation are used which enable local cerebral glucose consumption to be calculated in terms of the following measurable variables: gray matter, white matter, and whole brain metabolic rates, calculated as a weighted average based on the approximate volume of each structure.
Journal ArticleDOI
Noninvasive determination of local cerebral metabolic rate of glucose in man
TL;DR: The rate constants of FDG in man were found to be comparable to those of deoxyglucose in rat and in rhesus monkey and the subject-to-subject variation of LCMRGlc as measured by the present method was comparable to that of other methods that measure whole-brain CMRglc.
Journal ArticleDOI
Tomographic measurement of local cerebral glucose metabolic rate in humans with (f-18)2-fluoro-2-deoxy-d-glucose: validation of method
TL;DR: The data indicate that cerebral FDG-6-PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.
Journal ArticleDOI
Cerebral metabolism and atrophy in huntington's disease determined by 18FDG and computed tomographic scan
David E. Kuhl,Michael E. Phelps,Charles H. Markham,E. Jeffrey Metter,Walter H. Riege,James Winter +5 more
TL;DR: The results suggest the possibility that the caudate may be hypometabolic in some asymptomatic subjects who are potential carriers of the autosomal dominant gene for HD.