J
Joel H. Greenberg
Researcher at University of Pennsylvania
Publications - 220
Citations - 11574
Joel H. Greenberg is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Cerebral blood flow & Ischemia. The author has an hindex of 54, co-authored 218 publications receiving 10924 citations. Previous affiliations of Joel H. Greenberg include University of Miami & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man.
Martin Reivich,David E. Kuhl,Alfred P. Wolf,Joel H. Greenberg,Michael E. Phelps,T. Ido,V Casella,Joanna S. Fowler,Eric A. Hoffman,Abass Alavi,Peter M. Som,L. Sokoloff +11 more
TL;DR: A mathematical model and derived operational equation are used which enable local cerebral glucose consumption to be calculated in terms of the following measurable variables: gray matter, white matter, and whole brain metabolic rates, calculated as a weighted average based on the approximate volume of each structure.
Journal ArticleDOI
Magnetic resonance imaging of glutamate
Kejia Cai,Mohammad Haris,Anup Singh,Feliks Kogan,Joel H. Greenberg,Hari Hariharan,John A. Detre,Ravinder Reddy +7 more
TL;DR: In a rat brain tumor model with blood-brain barrier disruption, intravenous glutamate injection resulted in a clear elevation of GluCEST and a similar increase in the proton magnetic resonance spectroscopy signal of glutamate, demonstrating the feasibility of using GLUCEST for mapping relative changes in glutamate concentration, as well as pH, in vivo.
Journal ArticleDOI
Glucose metabolic rate kinetic model parameter determination in humans: the lumped constants and rate constants for [18F]fluorodeoxyglucose and [11C]deoxyglucose.
Martin Reivich,Abass Alavi,Alfred P. Wolf,Joanna S. Fowler,J.A.G. Russell,Carroll D. Arnett,Robert R. MacGregor,Chyng-Yann Shiue,Harold L. Atkins,A. Anand,R. Dann,Joel H. Greenberg +11 more
TL;DR: Using the rate constants and lumped constants determined in humans for the glucose metabolic rate kinetic model used to measure local cerebral glucose consumption, the average whole-brain metabolic rates for glucose in normal subjects measured with [18F]FDG and [11C]DG are 5.66 ± 0.37 (n = 6) and 4.99 mg/100 g/min, respectively.
Journal ArticleDOI
Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia.
Joseph P. Culver,Turgut Durduran,Daisuke Furuya,Cecil Cheung,Joel H. Greenberg,Arjun G. Yodh +5 more
TL;DR: The authors report DOT images of hemodynamic and metabolic contrasts using a rat middle cerebral artery occlusion (MCAO) stroke model, and demonstrates how these hemodynamic measures can be synthesized to calculate an index of the oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen consumption (CMRo2).
Journal ArticleDOI
Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation.
Turgut Durduran,Guoqiang Yu,Mark G. Burnett,John A. Detre,Joel H. Greenberg,Jiongjiong Wang,Chao Zhou,Arjun G. Yodh +7 more
TL;DR: The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is demonstrated, and the clinical potential of this hybrid, all-optical nonin invasive, methodology can now be explored.