D
David F. Stern
Researcher at Massachusetts Institute of Technology
Publications - 8
Citations - 1870
David F. Stern is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Monoclonal antibody & Gene. The author has an hindex of 6, co-authored 8 publications receiving 1819 citations. Previous affiliations of David F. Stern include Harvard University.
Papers
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Journal ArticleDOI
The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen.
Alan L. Schechter,David F. Stern,Lalitha Vaidyanathan,Stuart J. Decker,Jeffrey A. Drebin,Mark I. Greene,Robert A. Weinberg +6 more
TL;DR: A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185), which is serologically related to the epidermal growth factor (EGF) receptor.
Journal ArticleDOI
Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies.
Jeffrey A. Drebin,Victoria C. Link,Victoria C. Link,David F. Stern,Robert A. Weinberg,Mark I. Greene,Mark I. Greene +6 more
TL;DR: Results suggest that p185 is required to maintain transformation induced by the neu oncogene, as determined by anchorage-independent growth of cells from the ethylnitrosourea-induced rat neuroblastoma line.
Journal ArticleDOI
Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene
TL;DR: In this article, the authors identify cell-surface antigens associated with the neoplastic process, and generate hybridomas which secrete monoclonal antibodies that react specifically with cell surface determinants found on a group of rat neuroblastoma oncogenes.
Patent
Methods and artificial genes for antagonizing the function of an oncogene
TL;DR: In this article, a method of antagonizing the effects of an oncogene by constructing an artificial gene which antagonizes the function of the oncogen is described, in one embodiment, the artificial gene comprises a transcriptional promoter segment, an inverted ONcogene segment, and a polyadenylation segment.