J
Jeffrey A. Drebin
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 229
Citations - 16959
Jeffrey A. Drebin is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 53, co-authored 190 publications receiving 14469 citations. Previous affiliations of Jeffrey A. Drebin include Hospital of the University of Pennsylvania & Harvard University.
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Journal ArticleDOI
Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma
Udaya K. Liyanage,Todd T. Moore,Hong-Gu Joo,Yoshiyuki Tanaka,Virginia Herrmann,Gerard M. Doherty,Jeffrey A. Drebin,Steven M. Strasberg,Timothy J. Eberlein,Peter S. Goedegebuure,David C. Linehan +10 more
TL;DR: It is concluded that the prevalence of Treg is increased in the peripheral blood as well as in the tumor microenvironment of patients with invasive breast or pancreas cancers, and may partly explain the poor immune response against tumor Ags.
Journal ArticleDOI
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Cosimo Commisso,Shawn M. Davidson,Rengin G. Soydaner-Azeloglu,Seth J. Parker,Jurre J. Kamphorst,Sean R. Hackett,Elda Grabocka,Michel Nofal,Jeffrey A. Drebin,Craig B. Thompson,Joshua D. Rabinowitz,Christian M. Metallo,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Dafna Bar-Sagi +14 more
TL;DR: In this paper, it was shown that Ras-transformed cells use macropinocytosis to transport extracellular protein into the cell, yielding amino acids including glutamine that can enter central carbon metabolism.
Journal ArticleDOI
The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen.
Alan L. Schechter,David F. Stern,Lalitha Vaidyanathan,Stuart J. Decker,Jeffrey A. Drebin,Mark I. Greene,Robert A. Weinberg +6 more
TL;DR: A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185), which is serologically related to the epidermal growth factor (EGF) receptor.
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Cosimo Commisso,Shawn M. Davidson,Rengin G. Soydaner-Azeloglu,Seth J. Parker,Jurre J. Kamphorst,Sean R. Hackett,Elda Grabocka,Michel Nofal,Jeffrey A. Drebin,Craig B. Thompson,Joshua D. Rabinowitz,Christian M. Metallo,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Dafna Bar-Sagi +14 more
TL;DR: It is shown that Ras-transformed cells use macropinocytosis to transport extracellular protein into the cell, and its pharmacological inhibition compromises the growth of Ras- transformed pancreatic tumour xenografts.
Journal ArticleDOI
Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
Mara H. Sherman,Ruth T. Yu,Dannielle D. Engle,Ning Ding,Annette R. Atkins,Hervé Tiriac,Eric A. Collisson,Frances Connor,Terry Van Dyke,Serguei Kozlov,Philip Martin,Tiffany W. Tseng,David W. Dawson,Timothy R. Donahue,Atsushi Masamune,Tooru Shimosegawa,Minoti V. Apte,Jeremy S. Wilson,Beverly Ng,Beverly Ng,Sue Lynn Lau,Sue Lynn Lau,Sue Lynn Lau,Jenny E. Gunton,Geoffrey M. Wahl,Tony Hunter,Jeffrey A. Drebin,Peter J. O'Dwyer,Christopher Liddle,David A. Tuveson,Michael Downes,Ronald M. Evans,Ronald M. Evans +32 more
TL;DR: It is shown that VDR acts as a master transcriptional regulator of PSCs to reprise the quiescent state, resulting in induced stromal remodeling, increased intratumoral gemcitabine, reduced tumor volume, and a 57% increase in survival compared to chemotherapy alone.