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David G. Binion
Researcher at Children's Hospital of Wisconsin
Publications - 10
Citations - 1145
David G. Binion is an academic researcher from Children's Hospital of Wisconsin. The author has contributed to research in topics: Endothelial stem cell & Angiogenesis. The author has an hindex of 9, co-authored 10 publications receiving 1062 citations. Previous affiliations of David G. Binion include Medical College of Wisconsin.
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Journal ArticleDOI
Angiogenic Effects of Interleukin 8 (CXCL8) in Human Intestinal Microvascular Endothelial Cells Are Mediated by CXCR2
Jan Heidemann,Hitoshi Ogawa,Michael B. Dwinell,Parvaneh Rafiee,Christian Maaser,Henning R. Gockel,Mary F. Otterson,David M. Ota,Norbert Lügering,Wolfram Domschke,David G. Binion +10 more
TL;DR: Supporting the notion that malignant colonic epithelial cells overexpress IL-8, CXCR2 blockade may be a novel target for anti-angiogenic therapy in colorectal adenocarcinoma.
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Infliximab retreatment in adults and children with Crohn’s disease: risk factors for the development of delayed severe systemic reaction
Subra Kugathasan,Michael B. Levy,Kia Saeian,Sotirios Vasilopoulos,Joseph P. Kim,Devang Prajapati,Jeanne Emmons,Alfonso Martinez,Kevin J. Kelly,David G. Binion +9 more
TL;DR: Infliximab retreatment in adults and children with Crohn's disease and risk factors for the development of delayed severe systemic reaction are studied.
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Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease.
David G. Binion,Gail A. West,Emily E. Volk,Judith A. Drazba,Nicholas P. Ziats,Robert E. Petras,Claudio Fiocchi +6 more
TL;DR: Because interaction between endothelial cells and leucocytes is a key regulatory step in the inflammatory process, this enhanced binding may contribute to the pathophysiology of chronic intestinal inflammation.
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Human Intestinal Microvascular Endothelial Cells Express Toll-Like Receptor 5: A Binding Partner for Bacterial Flagellin
Christian Maaser,Jan Heidemann,Christof von Eiff,Andreas Lügering,Thomas W. Spahn,David G. Binion,Wolfram Domschke,Norbert Lügering,Torsten Kucharzik +8 more
TL;DR: It is found that Salmonella-infected intestinal epithelial cells induce endothelial ICAM-1 expression in cocultured human endothelial cells, suggesting that endothelially expressed TLR5 might play a previously unrecognized role in the innate immune response toward bacterial Ags.
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Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells
Hitoshi Ogawa,Parvaneh Rafiee,Jan Heidemann,Pamela J. Fisher,Nathan A. Johnson,Mary F. Otterson,Balaraman Kalyanaraman,Kirkwood A. Pritchard,David G. Binion +8 more
TL;DR: HIMEC exhibit endotoxin tolerance after repeat LPS exposure in vitro, characterized by diminished activation and intracellular superoxide anion concentration, and reduced leukocyte adhesion.