Angiogenic Effects of Interleukin 8 (CXCL8) in Human Intestinal Microvascular Endothelial Cells Are Mediated by CXCR2
Jan Heidemann,Hitoshi Ogawa,Michael B. Dwinell,Parvaneh Rafiee,Christian Maaser,Henning R. Gockel,Mary F. Otterson,David M. Ota,Norbert Lügering,Wolfram Domschke,David G. Binion +10 more
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TLDR
Supporting the notion that malignant colonic epithelial cells overexpress IL-8, CXCR2 blockade may be a novel target for anti-angiogenic therapy in colorectal adenocarcinoma.About:
This article is published in Journal of Biological Chemistry.The article was published on 2003-03-07 and is currently open access. It has received 465 citations till now. The article focuses on the topics: Angiogenesis & Interleukin 8.read more
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Muscle as an endocrine organ: focus on muscle-derived interleukin-6.
TL;DR: This review focuses on the myokine IL-6, its regulation by exercise, its signaling pathways in skeletal muscle, and its role in metabolism in both health and disease.
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
TL;DR: This review will focus on the role of the main cytokines, chemokines, and their receptors in the pathophysiology of auto-inflammatory disorders, pro- inflammatory disorders, and neurological disorders involving inflammation.
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Chronic inflammation and cytokines in the tumor microenvironment.
TL;DR: The role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis are explored.
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The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages
TL;DR: The role of TAM in the inflammatory micro-environment of solid tumors is discussed and a potential target for future therapeutic approaches is identified.
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CXC chemokines in angiogenesis.
TL;DR: Members that contain the 'ELR' motif are potent promoters of angiogenesis, and mediate their angiogenic activity via binding and activating CXCR2 on endothelium, while those that are inducible by interferons and lack the ELR motif (ELR-) are potent inhibitors ofAngiogenesis.
References
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Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.
Michael S. O'Reilly,Thomas Boehm,Yuen Shing,Naomi Fukai,George Vasios,William S. Lane,Evelyn Flynn,James R Birkhead,Bjorn R. Olsen,Judah Folkman +9 more
TL;DR: This work has identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma, a 20 kDa C-terminal fragment of collagen XVIII that specifically inhibits endothelial proliferation and potently inhibitsAngiogenesis and tumor growth.
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Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells
TL;DR: To explore the role of cyclooxygenase (COX) in endothelial cell migration and angiogenesis, two in vitro model systems involving coculture of endothelial cells with colon carcinoma cells are used.
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Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis
Alisa E. Koch,Peter J. Polverini,Steven L. Kunkel,Lisa A. Harlow,Luisa A. DiPietro,Victor M. Elner,Susan G. Elner,Robert M. Strieter +7 more
TL;DR: A function for macrophage-derived IL-8 in angiogenesis-dependent disorders such as rheumatoid arthritis, tumor growth, and wound repair is suggested.
Journal Article
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Philip M. Murphy,Marco Baggiolini,Israel F. Charo,Caroline A. Hébert,Richard Horuk,Kouji Matsushima,Louis H. Miller,Joost J. Oppenheim,Christine A. Power +8 more
TL;DR: A widely accepted receptor nomenclature system is described, ratified by the International Union of Pharmacology, that is facilitating clear communication in this area and updating current concepts of the biology and pharmacology of the chemokine system.
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Angiostatin induces and sustains dormancy of human primary tumors in mice
TL;DR: It is shown that systemic administration of human angiostatin potently inhibits the growth of three human and three murine primary carcinomas in mice, the first demonstration of dormancy therapy, a novel anticancer strategy in which malignant tumors are regressed by prolonged blockade of angiogenesis.