D
David H. Orth
Researcher at Memorial Hospital of South Bend
Publications - 19
Citations - 7001
David H. Orth is an academic researcher from Memorial Hospital of South Bend. The author has contributed to research in topics: Macular degeneration & Age-Related Eye Disease Study. The author has an hindex of 15, co-authored 19 publications receiving 6335 citations. Previous affiliations of David H. Orth include Rush University.
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Journal ArticleDOI
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8
A. Kassoff,J. Kassoff,J. Buehler,M. Eglow,F. Kaufman,M. Mehu,S. Kieval,M. Mairs,B. Graig,A. Quattrocchi,David R. Jones,J. Locatelli,Alan J. Ruby,A Jr Capon,Bruce R. Garretson,Tarek S Hassan,Michael T. Trese,George A. Williams,V. Regan,P. Manatrey,P. Streasick,L. Szydlowski,F. McIver,C. Bridges,C. Stanley,K. Cumming,B. Lewis,Mary Zajechowski,R. R. Margherio,M. S. Cox,J. C. Werner,R. Falk,P. Siedlak,C. Neubert,Michael L. Klein,J. T. Stout,A. O'Malley,Andreas K. Lauer,Joseph E. Robertson,David J. Wilson,C. Beardsley,H. Anderson,P. Wallace,G. Smith,Shannon Howard,Richard F. Dreyer,C. Ma,R. G. Chenoweth,John Zilis,M. Johnson,Patrick B. Rice,H. Daniel,H. Crider,Stuart G Parker,K. Sherman,Daniel F. Martin,T M Sr Aaberg,P Jr Sternberg,Linda Curtis,B. Ju,James Gilman,B. Myles,S. Strittman,Christina Gentry,H. Yi,A Jr Capone,M. Lambert,Travis A. Meredith,T M Jr Aaberg,D. Saperstein,J. I. Lim,B. Stribling,D. Armiger,R. Swords,David H. Orth,T. P. Flood,J. Civantos,S. deBustros,Kirk H. Packo,Pauline T. Merrill,J. A. Cohen,Celeste Figliulo,Chris Morrison,D. A. Bryant,Don Doherty,M. McVicker,T. Drefcinski,J. M. Seddon,M. K. Pinnolis,N. Davis,I. Burton,T. Taitsel,David I. Walsh,J. Dubois-Moran,C. Callahan,Claudia Evans,K. K. Snow,D. A. Jones-Devonish,V. D. Crouse +98 more
TL;DR: People older than 55 years should have dilated eye examinations to determine their risk of developing advanced AMD and those with extensive intermediate size drusen, at least 1 large druse, noncentral geographic atrophy in 1 or both eyes, or advanced AMD or vision loss due to AMD in 1 eye should consider taking a supplement of antioxidants plus zinc.
Journal ArticleDOI
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial
Emily Y. Chew,Traci E Clemons,John Paul SanGiovanni,Ronald P. Danis,Frederick L. Ferris,Michael J. Elman,Andrew N. Antoszyk,Alan J. Ruby,David H. Orth,Susan B. Bressler,Gary E. Fish,Baker Hubbard,Michael L. Klein,Suresh R. Chandra,Barbara A Blodi,Amitha Domalpally,Thomas R. Friberg,Wai T. Wong,Philip J. Rosenfeld,Elvira Agrón,Cynthia A. Toth,Paul S. Bernstein,Robert Sperdut +22 more
TL;DR: Addition of lutein + zeaxanthin, DHA + EPA, or both to the AREDS formulation in primary analyses did not reduce risk of progression to advanced AMD, but because of potential increased incidence of lung cancer in former smokers, luteIn + zexanthin could be an appropriate carotenoid substitute in the ARedS formulation.
Journal ArticleDOI
Evaluation of Grid Pattern Photocoagulation for Macular Edema in Central Vein Occlusion: The Central Vein Occlusion Study Group M Report
John G. Clarkson,Elaine Chuang,Donald Gass,Maria Pedroso,Tony Cubillas,Erlinda S. Duria,Ditte J. Hess,Isabel Rams,Marguerite Ball,Alex Gutierrez,Nayla Muniz,June Thompson,Michele Pall,Charles J. Pappas,Daniel Finkelstein,Arnall Patz,Dolores Rytel,Judy Belt,Dennis Cain,Terri Cain,David Emmert,Terry George,Mark Herring,Pete Sotirakos,David H. Orth,Timothy P. Flood,Kirk H. Packo,Toni Larsen,Nancy Perez,D. A. Bryant,Don Doherty,Jay Fitzgerald,Martha Gordon,Cynthia Holod,Kathy Kwiatkowski,Celeste MacLeod,Chris Morrison,Charlotte Westcott,Michael L. Klein,David J. Wilson,Richard G. Weleber,Susan K. Nolte,Nancy Hurlburt,Mark Evans,Patrick Wallace,Peter N. Steinkamp,Debora Funkner,Cathy Gordon,Clement L. Trempe,Alex E. Jalkh,John J. Weiter,Sherry Anderson,Dennis Donovan,Tom O'Day,Gerald R. Friedman,Rodney L. Immerman,Gabriel Coscas,Gisèle Soubrane,Rose Marie Haran,Christophe Debibie,Jean Gizelsky,Ingolf H. L. Wallow,Guillermo de Venecia,George Bresnick,Sandra Larson,Sandy Fuller,Bob Harrison,Gene Knutson,Michael W. Neider,Greg Weber,Ruth Bahr,Bonnie Grosnick,Robert Lazorik,Helen Lyngaas,Diane Quackenboss,Guy Somers,Froncie A. Gutman,Sanford Myers,Tina Kiss,Deborah Ross,Pamela Vargo,Janet Edgarton,Sue Hanson,Janet Nader,Nancy Tomsak,Lawrence J. Singerman,Hernando Zegarra,Susan Lichterman,Adrienne Fowler Kramer,Sheila Smith-Brewer,Pam Brown Rowe,Geraldine Daley,Anne Pinter,Kathy Coreno,Lori Cooper,Marty Delisio,Donna Cross,Wendy Lord,Argye Hillis,Mark W. Riggs,Cheryl Kasberg-Preece,M. Hasan Rajab,Krista Carlson Giniewicz,Kevin Gilmore,Carol Zimmerman,Mary Lou Lewis,Maria Cristina Wells,Julie Lord Forbes,Kathleen C. Fetzer,Heather McNish,George H. Bresnick,Lissa McNulty,Jim Baliker,Linda Alanen,Laura Gentry,Richard L. Mowery,Donald F. Everett,Robert J. Hardy,Gary W. Abrams,Robert N. Frank,Maureen G. Maguire,Abner V. McCall +121 more
TL;DR: In this article, the efficacy of macular grid photocoagulation in preserving or improving central visual acuity in eyes with macular edema due to central vein occlusion was evaluated.
Journal ArticleDOI
The Age-Related Eye Disease Study (AREDS): Design Implications AREDS Report No. 1
A. S. Lindblad,A. Kassoff,S. Kieval,M. Mehu,J. Buehler,M. Eglow,F. Kaufman,R. R. Margherio,M. S. Cox,B. Garretson,T. Hassan,A. Ruby,Michael T. Trese,J. C. Werner,George A. Williams,V. Regan,P. Manatrey,K. Cumming,M. Zajechowski,R. Falk,P. Streasick,L. Szydlowski,R. F. Dreyer,C. Ma,C. Beardsley,H. Crider,A Jr Capone,T. M. Aaberg,Dan Martin,D. Saperstein,P Jr Sternberg,L. Curtis,B. Stribling,James Gilman,B. Myles,R. Swords,David H. Orth,T. P. Flood,J. Civantos,S. deBustros,Kirk H. Packo,C. MacLeod,C. Morrison,D. A. Bryant,D. Doherty,S. Sandoval,J. M. Seddon,M. K. Pinnolis,D. A. Jones-Devonish,V. D. Crouse,K. K. Snow,C. Evans,N. Davis,C. Callahan,D. Walsh,J. Dubois,I. Burton,Frederick L. Ferris,E. Y. Chew,K. Csaky,S. A. McCarthy,K. H. Dabas,L. Goodman,Ja Kim Young Ja Kim,P. Lopez,R. Mercer,L. M. Ayres,T. LaRean,A. Randall,M. Chicca,P. F. Ciatto,E. Kuehl,I. Kivitz,D. Koutsandreas,Thomas R. Friberg,Andrew W. Eller,Michael B. Gorin,J. Alexander,B. Mack,S. B. Bressler,Neil M. Bressler,G. Cassel,M. Goldberg,J. A. Haller,L. Ratner,Andrew Schachat,S. H. Sherman,J. S. Sunness,S. Schenning,C. Sackett,Dennis Cain,D. Emmert,T. George,S. Wheeler,M. J. Elman,R. Ballinger,A. Betancourt,David B. Glasser,J. Lammlein +98 more
TL;DR: The AREDS design, including the study rationale and operational structure, and the approach adopted to combine, for two diseases, clinical trials with a natural history study are described.
Journal ArticleDOI
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins c and e and beta carotene for age-related cataract and vision loss: AREDS report no. 9
A. Kassoff,J. Kassoff,J. Buehler,M. Eglow,F. Kaufman,M. Mehu,S. Kieval,M. Mairs,B. Graig,A. Quattrocchi,David R. Jones,J. Locatelli,Alan J. Ruby,A Jr Capone,Bruce R. Garretson,Tarek S Hassan,Michael T. Trese,George A. Williams,V. Regan,P. Manatrey,P. Streasick,L. Szydlowski,F. McIver,C. Bridges,C. Stanley,K. Cumming,B. Lewis,Mary Zajechowski,R. R. Margherio,M. S. Cox,J. C. Werner,R. Falk,P. Siedlak,C. Neubert,Michael L. Klein,Tim Stout,A. O'Malley,Andreas K. Lauer,Joseph E. Robertson,David J. Wilson,C. Breadsley,H. Anderson,P. Wallace,G. Smith,Shannon Howard,Richard F. Dreyer,C. Ma,R. G. Chenoweth,John Zilis,M. Johnson,Patrick B. Rice,H. Daniel,H. Crider,Stuart G Parker,K. Sherman,Daniel F. Martin,T M Sr Aaberg,P Jr Sternberg,Linda Curtis,B. Ju,James Gilman,B. Myles,S. Strittman,Christina Gentry,H. Yi,M. Lambert,Travis A. Meredith,T M Jr Aaberg,D. Saperstein,J. I. Lim,B. Stribling,D. Armiger,R. Swords,David H. Orth,T. P. Flood,J. Civantos,S. De Bustros,Kirk H. Packo,Pauline T. Merrill,J. A. Cohen,Celeste Figliulo,Chris Morrison,D. A. Bryant,Don Doherty,M. McVicker,T. Drefcinski,J. M. Seddon,M. K. Pinnolis,N. Davis,I. Burton,T. Taitsel,David I. Walsh,J. Dubois-Moran,C. Callahan,Claudia Evans,K. K. Snow,D. A. Jones-Devonish,V. D. Crouse +97 more
TL;DR: Use of a high-dose formulation of vitamin C, vitamin E, and beta carotene in a relatively well-nourished older adult cohort had no apparent effect on the 7-year risk of development or progression of age-related lens opacities or visual acuity loss.