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Paul S. Bernstein
Researcher at University of Utah
Publications - 291
Citations - 16796
Paul S. Bernstein is an academic researcher from University of Utah. The author has contributed to research in topics: Zeaxanthin & Lutein. The author has an hindex of 62, co-authored 291 publications receiving 14734 citations. Previous affiliations of Paul S. Bernstein include University of California, Los Angeles & Columbia University.
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Journal ArticleDOI
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial
Emily Y. Chew,Traci E Clemons,John Paul SanGiovanni,Ronald P. Danis,Frederick L. Ferris,Michael J. Elman,Andrew N. Antoszyk,Alan J. Ruby,David H. Orth,Susan B. Bressler,Gary E. Fish,Baker Hubbard,Michael L. Klein,Suresh R. Chandra,Barbara A Blodi,Amitha Domalpally,Thomas R. Friberg,Wai T. Wong,Philip J. Rosenfeld,Elvira Agrón,Cynthia A. Toth,Paul S. Bernstein,Robert Sperdut +22 more
TL;DR: Addition of lutein + zeaxanthin, DHA + EPA, or both to the AREDS formulation in primary analyses did not reduce risk of progression to advanced AMD, but because of potential increased incidence of lung cancer in former smokers, luteIn + zexanthin could be an appropriate carotenoid substitute in the ARedS formulation.
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Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration
Rando Allikmets,Noah F. Shroyer,Nanda A. Singh,Johanna M. Seddon,Richard A. Lewis,Paul S. Bernstein,Andy Peiffer,Norman A. Zabriskie,Yixin Li,Amy Hutchinson,Michael Dean,James R. Lupski,Mark Leppert +12 more
TL;DR: Identification of ABCR alterations will permit presymptomatic testing of high-risk individuals and may lead to earlier diagnosis of AMD and to new strategies for prevention and therapy.
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A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
Zhenglin Yang,Nicola J. Camp,Hui Sun,Zongzhong Tong,Daniel Gibbs,D. Joshua Cameron,Haoyu Chen,Yu Zhao,Erik G. Pearson,Xi Li,Jeremy Chien,Andrew T. DeWan,Jennifer Harmon,Paul S. Bernstein,Viji Shridhar,Norman A. Zabriskie,Josephine Hoh,Kimberly A. Howes,Kang Zhang +18 more
TL;DR: A single-nucleotide polymorphism in the promoter region of HTRA1 is the most likely causal variant for AMD at 10q26 and is estimated to confer a population attributable risk of 49.3%.
Journal ArticleDOI
Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health.
Frederick Khachik,Lorena S. Carvalho,Paul S. Bernstein,Garth J. Muir,Da You Zhao,Nikita B. Katz +5 more
TL;DR: The complete spectrum of carotenoids was identified and quantified from pooled human retinal pigment epithelium, ciliary body, iris, lens, and in the uveal tract and in other tissues of the human eye to gain a better insight into the metabolic pathways of ocular carotanoids.
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Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
Benjamin M. Neale,Jesen Fagerness,Jesen Fagerness,Robyn Reynolds,Lucia Sobrin,Margaret M. Parker,Soumya Raychaudhuri,Soumya Raychaudhuri,Perciliz L. Tan,Edwin C. Oh,Joanna E. Merriam,Eric H. Souied,Paul S. Bernstein,Binxing Li,Jeanne M. Frederick,Kang Zhang,Kang Zhang,Milam A. Brantley,Aaron Y. Lee,Donald J. Zack,Betsy Campochiaro,Peter A. Campochiaro,Stephan Ripke,Stephan Ripke,R. Theodore Smith,Gaetano R. Barile,Nicholas Katsanis,Rando Allikmets,Mark J. Daly,Mark J. Daly,Johanna M. Seddon +30 more
TL;DR: A genome-wide association study of advanced age-related macular degeneration cases and controls using the Affymetrix 6.0 platform implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD.