D
David R. Jones
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 780
Citations - 48502
David R. Jones is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 87, co-authored 707 publications receiving 40501 citations. Previous affiliations of David R. Jones include University of Virginia Health System & St George's Hospital.
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Journal ArticleDOI
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8
A. Kassoff,J. Kassoff,J. Buehler,M. Eglow,F. Kaufman,M. Mehu,S. Kieval,M. Mairs,B. Graig,A. Quattrocchi,David R. Jones,J. Locatelli,Alan J. Ruby,A Jr Capon,Bruce R. Garretson,Tarek S Hassan,Michael T. Trese,George A. Williams,V. Regan,P. Manatrey,P. Streasick,L. Szydlowski,F. McIver,C. Bridges,C. Stanley,K. Cumming,B. Lewis,Mary Zajechowski,R. R. Margherio,M. S. Cox,J. C. Werner,R. Falk,P. Siedlak,C. Neubert,Michael L. Klein,J. T. Stout,A. O'Malley,Andreas K. Lauer,Joseph E. Robertson,David J. Wilson,C. Beardsley,H. Anderson,P. Wallace,G. Smith,Shannon Howard,Richard F. Dreyer,C. Ma,R. G. Chenoweth,John Zilis,M. Johnson,Patrick B. Rice,H. Daniel,H. Crider,Stuart G Parker,K. Sherman,Daniel F. Martin,T M Sr Aaberg,P Jr Sternberg,Linda Curtis,B. Ju,James Gilman,B. Myles,S. Strittman,Christina Gentry,H. Yi,A Jr Capone,M. Lambert,Travis A. Meredith,T M Jr Aaberg,D. Saperstein,J. I. Lim,B. Stribling,D. Armiger,R. Swords,David H. Orth,T. P. Flood,J. Civantos,S. deBustros,Kirk H. Packo,Pauline T. Merrill,J. A. Cohen,Celeste Figliulo,Chris Morrison,D. A. Bryant,Don Doherty,M. McVicker,T. Drefcinski,J. M. Seddon,M. K. Pinnolis,N. Davis,I. Burton,T. Taitsel,David I. Walsh,J. Dubois-Moran,C. Callahan,Claudia Evans,K. K. Snow,D. A. Jones-Devonish,V. D. Crouse +98 more
TL;DR: People older than 55 years should have dilated eye examinations to determine their risk of developing advanced AMD and those with extensive intermediate size drusen, at least 1 large druse, noncentral geographic atrophy in 1 or both eyes, or advanced AMD or vision loss due to AMD in 1 eye should consider taking a supplement of antioxidants plus zinc.
Journal ArticleDOI
Genomic Classification and Prognosis in Acute Myeloid Leukemia
Elli Papaemmanuil,Moritz Gerstung,Lars Bullinger,Verena I. Gaidzik,Peter Paschka,Nicola D. Roberts,Nicola E. Potter,Michael Heuser,Felicitas Thol,Niccolo Bolli,Gunes Gundem,Peter Van Loo,Inigo Martincorena,Peter Ganly,Laura Mudie,Stuart McLaren,Sarah O’Meara,Keiran Raine,David R. Jones,Jon W. Teague,Adam Butler,Mel Greaves,Arnold Ganser,Konstanze Döhner,Richard F. Schlenk,Hartmut Döhner,Peter J. Campbell +26 more
TL;DR: The driver landscape in AML reveals distinct molecular subgroups that reflect discrete paths in the evolution of AML, informing disease classification and prognostic stratification.
Journal ArticleDOI
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
Fan Yeung,Jamie E. Hoberg,Catherine S. Ramsey,Michael D Keller,David R. Jones,Roy A. Frye,Marty W. Mayo +6 more
TL;DR: It is demonstrated that SIRT1, a nicotinamide adenosine dinucleotide‐dependent histone deacetylase, regulates the transcriptional activity of NF‐κB and activity augments apoptosis in response to TNFα.
Journal Article
Evaluating patient-based outcome measures for use in clinical trials.
TL;DR: This research highlights the need to understand more fully the rationale behind the continued use of these devices, as well as the barriers to their adoption.
Journal ArticleDOI
Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2
Jyoti Nangalia,Charles E. Massie,E J Baxter,Francesca L. Nice,Gunes Gundem,David C. Wedge,Edward Avezov,Juan Li,Karoline Kollmann,David G. Kent,Athar Aziz,Anna L. Godfrey,Jonathon Hinton,Inigo Martincorena,P Van Loo,Amy V. Jones,Paola Guglielmelli,P. S. Tarpey,Heather P. Harding,J.D. Fitzpatrick,C.T. Goudie,Christina A. Ortmann,Stephen J. Loughran,Keiran Raine,David R. Jones,Adam Butler,Jon W. Teague,Sarah O’Meara,Stuart McLaren,M. Bianchi,Yvonne Silber,D. Dimitropoulou,David Bloxham,L. Mudie,Mark Maddison,Bruce W. S. Robinson,Clodagh Keohane,Cathy MacLean,Kate Hill,Kim Orchard,Sudhir Tauro,Ming-Qing Du,Mel Greaves,David G. Bowen,Brian J. P. Huntly,Claire N. Harrison,Nicholas C.P. Cross,David Ron,Alessandro M. Vannucchi,Elli Papaemmanuil,Peter J. Campbell,Anthony R. Green +51 more
TL;DR: Somatic mutations in the endoplasmic reticulum chaperone CALR were found in a majority of patients with myeloproliferative neoplasms with nonmutated JAK2, a finding consistent with its role as an initiating mutation in some patients.