抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

This paper gives the 2010 self-consistent set of values of the basic constants and conversion factors of physics and chemistry recommended by the Committee on Data for Science and Technology (CODATA) for international use. The 2010 adjustment takes into account the data considered in the 2006 adjustment as well as the data that became available from 1 January 2007, after the closing date of that adjustment, until 31 December 2010, the closing date of the new adjustment. Further, it describes in detail the adjustment of the values of the constants, including the selection of the final set of input data based on the results of least-squares analyses. The 2010 set replaces the previously recommended 2006 CODATA set and may also be found on the World Wide Web at physics.nist.gov/constants.

/pdf/codata-recommended-values-of-the-fundamental-physical-4bsdant71c.pdf

CODATA Recommended Values of the Fundamental Physical Constants: 2006

Quantum mechanics---the theory describing the fundamental workings of nature---is famously counterintuitive: it predicts that a particle can be in two places at the same time, and that two remote particles can be inextricably and instantaneously linked These predictions have been the topic of intense metaphysical debate ever since the theory's inception early last century However, supreme predictive power combined with direct experimental observation of some of these unusual phenomena leave little doubt as to its fundamental correctness In fact, without quantum mechanics we could not explain the workings of a laser, nor indeed how a fridge magnet operates Over the last several decades quantum information science has emerged to seek answers to the question: can we gain some advantage by storing, transmitting and processing information encoded in systems that exhibit these unique quantum properties? Today it is understood that the answer is yes Many research groups around the world are working towards one of the most ambitious goals humankind has ever embarked upon: a quantum computer that promises to exponentially improve computational power for particular tasks A number of physical systems, spanning much of modern physics, are being developed for this task---ranging from single particles of light to superconducting circuits---and it is not yet clear which, if any, will ultimately prove successful Here we describe the latest developments for each of the leading approaches and explain what the major challenges are for the future

Quantum Computing

We review the current status of single-photon-source and single-photon-detector technologies operating at wavelengths from the ultraviolet to the infrared. We discuss applications of these technologies to quantum communication, a field currently driving much of the development of single-photon sources and detectors.

/pdf/invited-review-article-single-photon-sources-and-detectors-5bsn8auo37.pdf

Invited review article: Single-photon sources and detectors

A measurement using a one-electron quantum cyclotron gives the electron magnetic moment in Bohr magnetons, g/2=1.001 159 652 180 73 (28) [0.28 ppt], with an uncertainty 2.7 and 15 times smaller than for previous measurements in 2006 and 1987. The electron is used as a magnetometer to allow line shape statistics to accumulate, and its spontaneous emission rate determines the correction for its interaction with a cylindrical trap cavity. The new measurement and QED theory determine the fine structure constant, with alpha{-1}=137.035 999 084 (51) [0.37 ppb], and an uncertainty 20 times smaller than for any independent determination of alpha.

New Measurement of the Electron Magnetic Moment and the Fine Structure Constant

A new measurement resolves cyclotron and spin levels for a single-electron quantum cyclotron to obtain an electron magnetic moment, given by g/2=1.001 159 652 180 85 (76) [0.76 ppt]. The uncertainty is nearly 6 times lower than in the past, and g is shifted downward by 1.7 standard deviations. The new g, with a quantum electrodynamics (QED) calculation, determines the fine structure constant with a 0.7 ppb uncertainty--10 times smaller than for atom-recoil determinations. Remarkably, this 100 mK measurement probes for internal electron structure at 130 GeV.

https://www.uni-ulm.de/fileadmin/website_uni_ulm/nawi.inst.220/lehre/Atomphysik_SS2008/gabrielse_g_Faktor_2006_PRL.pdf

New measurement of the electron magnetic moment using a one-electron quantum cyclotron.

Measurements with a one-electron quantum cyclotron determine the electron magnetic moment, given by $g/2=1.001 159 652 180 73(28)[0.28\mathrm{ppt}]$, and the fine structure constant, $\ensuremath{\alpha}{}^{\ensuremath{-}1}=137.035 999 084(51)[0.37\mathrm{ppb}]$. Announcements of these measurements [Phys. Rev. Lett. 97, 030801 (2006); 100, 120801 (2008)] are supplemented here with a more complete description of the one-electron quantum cyclotron and the measurement methods, a discussion of the cavity control of the radiation field, a summary of the analysis of the measurements, and a fuller discussion of the uncertainties.

Cavity control of a single-electron quantum cyclotron: Measuring the electron magnetic moment

Quantum electrodynamics (QED) predicts a relationship between the dimensionless magnetic moment of the electron ($g$) and the fine structure constant ($\ensuremath{\alpha}$). A new measurement of $g$ using a one-electron quantum cyclotron, together with a QED calculation involving 891 eighth-order Feynman diagrams, determine ${\ensuremath{\alpha}}^{\ensuremath{-}1}=137.035\text{ }999\text{ }710\text{ }(96)\text{ }[0.70\text{ }\text{ }\mathrm{ppb}]$. The uncertainties are 10 times smaller than those of nearest rival methods that include atom-recoil measurements. Comparisons of measured and calculated $g$ test QED most stringently, and set a limit on internal electron structure.

New Determination of the Fine Structure Constant from the Electron g Value and QED

Large-scale quantum information processors must be able to transport and maintain quantum information and repeatedly perform logical operations. Here, we show a combination of all of the fundamental elements required to perform scalable quantum computing through the use of qubits stored in the internal states of trapped atomic ions. We quantified the repeatability of a multiple-qubit operation and observed no loss of performance despite qubit transport over macroscopic distances. Key to these results is the use of different pairs of 9 Be + hyperfine states for robust qubit storage, readout, and gates, and simultaneous trapping of 24 Mg + “re-cooling” ions along with the qubit ions.

/pdf/complete-methods-set-for-scalable-ion-trap-quantum-1ezq5zy4ci.pdf

David Hanneke

Papers

New Measurement of the Electron Magnetic Moment and the Fine Structure Constant

New measurement of the electron magnetic moment using a one-electron quantum cyclotron.

Cavity control of a single-electron quantum cyclotron: Measuring the electron magnetic moment

New Determination of the Fine Structure Constant from the Electron g Value and QED

Complete Methods Set for Scalable Ion Trap Quantum Information Processing