David Ibberson

TL;DR: Evidence of an unanticipated dynamic role for DNA methylation in gene regulation in human cells is presented, and cyclical changes in the methylation status of promoter CpGs may represent a critical event in transcriptional achievement.

TL;DR: It is shown that cyclical methylation and demethylation of CpG dinucleotides, with a periodicity of around 100 min, is characteristic for five selected promoters, including the oestrogen (E2)-responsive pS2 gene, in human cells.

TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, like in the previous version of this paper.

TL;DR: This study presents a genome-scale investigation of H-NS and Fis binding to the E. coli chromosome using chromatin immunoprecipitation combined with high-throughput sequencing (ChIP-seq) and proposes that direct transcriptional regulation by Fis is associated with the interaction of tandem arrays of Fis molecules to the DNA and possible DNA bending, particularly at operon-upstream regions.

TL;DR: Meta-analysis of genes directly responsive to oestrogen indicates that VPA and TSA have a generally antioestrogenic profile in ERα positive cells, indicating that a limited number of genes signal a hyperacetylated state within cells.