F
Frank Gannon
Researcher at QIMR Berghofer Medical Research Institute
Publications - 229
Citations - 16076
Frank Gannon is an academic researcher from QIMR Berghofer Medical Research Institute. The author has contributed to research in topics: Gene & Estrogen receptor alpha. The author has an hindex of 54, co-authored 225 publications receiving 15596 citations. Previous affiliations of Frank Gannon include Queen's University Belfast & University of Tokyo.
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Journal ArticleDOI
Estrogen Receptor-α Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target Promoter
Raphaël Métivier,Graziella Penot,Michael R Hübner,George Reid,Heike Brand,Martin Kos,Frank Gannon +6 more
TL;DR: A comprehensive picture of events resulting in transcriptional activation of a gene is provided, through evaluating the estrogen receptor-alpha (NR3A1) target pS2 gene promoter in MCF-7 cells, which implies that transcriptionalactivation is a cyclical process that requires both activating and repressive epigenetic processes.
Journal ArticleDOI
A unified nomenclature system for the nuclear receptor superfamily
Johan Auwerx,E. Baulieu,Miguel Beato,M. Becker-Andre,P. H. Burbach,G. Camerino,P. Chambon,Austin J. Cooney,A. Dejean,C. Dreyer,Ronald M. Evans,Frank Gannon,Vincent Giguère,Hinrich Gronemeyer,Jan-Åke Gustafsson,Vincent Laudet,Mitchell A. Lazar,David J. Mangelsdorf,J. Millbrandt,E. Milgrom,David D. Moore,Bert W. O'Malley,M G Parker,K. Parker,T. Perimann,M. Pfahl,Michael G. Rosenfeld,H. Samuels,G. Schutz,Frances M. Sladek,Hendrik G. Stunnenberg,Michael Spedding,Carl S. Thummel,M. J. Tsai,K. Umesono,B. Vennstrom,Walter Wahli,C. Weinberg,Timothy M. Willson,K. Yamamoto +39 more
TL;DR: Over the last decade, workers in the field have described more than 300 sequences of NRs using an increasingly complex and baroque nomenclature, which constitutes a barrier for understanding of newly acquired knowledge to researchers outside as well as within the field.
Journal ArticleDOI
Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.
TL;DR: Selected regions of cloned EcoRI fragments of the chicken ovalbumin gene have been sequenced, and a previously unreported interruption in the DNA sequences coding for the 5' nontranslated region of the messenger has been discovered.
Journal ArticleDOI
Cyclical DNA methylation of a transcriptionally active promoter
Raphaël Métivier,Rozenn Gallais,Christophe Tiffoche,Christine Le Péron,Renata Z. Jurkowska,Richard P. Carmouche,David Ibberson,Peter Barath,Peter Barath,Florence Demay,George Reid,Vladimir Benes,Albert Jeltsch,Frank Gannon,Frank Gannon,Gilles Salbert +15 more
TL;DR: Evidence of an unanticipated dynamic role for DNA methylation in gene regulation in human cells is presented, and cyclical changes in the methylation status of promoter CpGs may represent a critical event in transcriptional achievement.
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Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line.
TL;DR: cDNA clones corresponding to a mRNA whose level is rapidly increased by addition of oestradiol to the culture medium have been isolated by differential screening of a cDNA library from the breast cancer cell line MCF-7, which contains oestrogen receptors.