George Reid

TL;DR: A comprehensive picture of events resulting in transcriptional activation of a gene is provided, through evaluating the estrogen receptor-alpha (NR3A1) target pS2 gene promoter in MCF-7 cells, which implies that transcriptionalactivation is a cyclical process that requires both activating and repressive epigenetic processes.

TL;DR: Evidence of an unanticipated dynamic role for DNA methylation in gene regulation in human cells is presented, and cyclical changes in the methylation status of promoter CpGs may represent a critical event in transcriptional achievement.

TL;DR: It is demonstrated that proteasome-mediated degradation and hER alpha-mediated transactivation are inherently linked and act to continuously turn over hERalpha on responsive promoters.

TL;DR: It is shown that cyclical methylation and demethylation of CpG dinucleotides, with a periodicity of around 100 min, is characteristic for five selected promoters, including the oestrogen (E2)-responsive pS2 gene, in human cells.

TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, like in the previous version of this paper.