D
David J. Baylink
Researcher at United States Department of Veterans Affairs
Publications - 55
Citations - 2509
David J. Baylink is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Bone cell & Growth factor. The author has an hindex of 25, co-authored 55 publications receiving 2466 citations. Previous affiliations of David J. Baylink include University of Rochester & Loma Linda University.
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IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms.
TL;DR: In conclusion, IGFBPs are unusually pleotrophic molecules with functions ranging from the traditional role of prolonging the half-life of the IGFs to functioning as growth factors independent ofThe IGFs.
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Age-related decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging.
V. Nicolas,A. Prewett,Paolo Bettica,Subburaman Mohan,Richard D. Finkelman,David J. Baylink,John R. Farley +6 more
TL;DR: A linear decline in the skeletal content of IGF-I (nanograms per mg protein) with donor age is found and that of TGF beta (r = -0.43; P < 0.001) in the total population.
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Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities.
Clifford J. Rosen,H.P. Dimai,D. Vereault,L.R. Donahue,Wesley G. Beamer,John R. Farley,Susan Linkhart,Thomas A. Linkhart,Subburaman Mohan,David J. Baylink +9 more
TL;DR: Analysis of circulatory and skeletal insulin-like growth factor-I and femoral bone mineral density in C3H and B6 progenitor strains and mice bred from subsequent F2 suggests that a possible mechanism for the difference in acquisition and maintenance of bone mass between these two inbred strains is related to systemic and skeletal IGF-I synthesis.
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Ovariectomy selectively reduces the concentration of transforming growth factor beta in rat bone: implications for estrogen deficiency-associated bone loss.
TL;DR: It is concluded that ovariectomy reduces deposition of TGF-beta in rat bone and that diminished skeletal T GF-beta could play a role in the pathogenesis of bone loss, fractures, and microfractures that occur in estrogen-deficient states.
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Changes in markers of bone formation and resorption in a bed rest model of weightlessness
TL;DR: The sequence of changes in the circulating markers of bone metabolism indicated that increases in serum OC are the earliest responses of bone to head‐down tilt bed rest.