W
Wesley G. Beamer
Researcher at Oklahoma Medical Research Foundation
Publications - 128
Citations - 8766
Wesley G. Beamer is an academic researcher from Oklahoma Medical Research Foundation. The author has contributed to research in topics: Bone density & Bone mineral. The author has an hindex of 48, co-authored 128 publications receiving 8497 citations.
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Journal ArticleDOI
Circulating levels of IGF-1 directly regulate bone growth and density
Shoshana Yakar,Clifford J. Rosen,Wesley G. Beamer,Cheryl L. Ackert-Bicknell,Yiping Wu,Jun-Li Liu,Guck T. Ooi,Jennifer Setser,Jan Frystyk,Yves R. Boisclair,Derek LeRoith +10 more
TL;DR: The double gene disruption LID+ALSKO mouse model demonstrates that a threshold concentration of circulating IGF-1 is necessary for normal bone growth and suggests that IGF- 1, IGFBP-3, and ALS play a prominent role in the pathophysiology of osteoporosis.
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Genetic variability in adult bone density among inbred strains of mice
TL;DR: Major genetic effects on femoral, vertebral, and phalangeal bone density are detectable among inbred strains of mice; cortical bone density shares common genetic regulation at the three measured sites; and within the femur, genes that regulate length and density are different.
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Murine mucopolysaccharidosis type VII. Characterization of a mouse with beta-glucuronidase deficiency.
Edward H. Birkenmeier,M T Davisson,Wesley G. Beamer,R E Ganschow,Carole Vogler,Babette Gwynn,K A Lyford,L M Maltais,C J Wawrzyniak +8 more
TL;DR: Surprisingly, a sensitive S1 nuclease assay indicated that the relative level of kidney gusmps mRNA responded normally to androgen induction by increasing approximately 11-fold, and may offer valuable information on the pathogenesis of human MPS VII.
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Atherogenic High-Fat Diet Reduces Bone Mineralization in Mice
Farhad Parhami,Yin Tintut,Wesley G. Beamer,Nima M. Gharavi,William G. Goodman,Linda L. Demer +5 more
TL;DR: Findings suggest that an atherogenic diet inhibits bone formation by blocking differentiation of osteoblast progenitor cells.
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Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6.
Eva M. Eicher,Wesley G. Beamer +1 more
TL;DR: Because the little mouse shares a number of similarities with the human ateliotic dwarfism, isolated growth hormones deficiency type I, it may be a useful animal model for this inherited human growth disorder.